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The New York Highlanders, predecessors of the New York Yankees, wear pinstripes uniforms for the first time while facing the Boston Red Sox in Opening Day at Hilltop Park. In the first inning, Boston scores a run against pitcher Ray Caldwell‚ while New York respond with two runs in the bottom against Smoky Joe Wood. That is all the scoring until the ninth inning‚ when the Sox score four runs‚ including two on a Wood single. Boston wins‚ 5–3‚ on Wood's seven hitter.
May 17 - Fenway Park is officially dedicated, almost one month after hosting its first game, as the Boston Red Sox host the Chicago White Sox playing in front of an overflow crowd. Nevertheless, the home town fans had their day spoiled as the White Sox trimmed the Red Sox, 5–2.
October 16 – The Boston Red Sox defeat the New York Giants, 3–2, in Game 8 of the World Series, ending one of the most exciting Series in Major League history. The Red Sox win the World Championship four games to three (with Game 2 being declared a tie). Nearly all of the games were close. Four games in this series were decided by one run. A fifth ended in a tie. A sixth was decided by two runs. Game 7 was the only one with a margin greater than three runs. Two games, including the decisive Game 8, went to extra innings. In Games 1 and 3, the losing team had the tying and winning runs on base when the game ended. This was the first time in which a World Series was decided in the last inning of the final game, in "sudden death" or "sudden victory" fashion. It was also the first Series where a team within one inning of losing came back to win. The next time a team that close to elimination recovered to win was in Game 6 of the 1986 Series.
January 11 – Lefty Marr, 49, outfielder/third baseman who hit .289 in 363 games for the Cincinnati Red Stockings, Columbus Solons, and Cincinnati Kelly's Killers from 1886 to 1891.
January 18 – John Russ, 53, outfielder/pitcher for the 1882 Baltimore Orioles of the American Association.
January 31 – Ed Taylor, 34, pitcher for the 1903 St. Louis Cardinals.
February 1 – Jim Doyle, 30, third baseman who hit .278 in two seasons with the Cincinnati Reds (1910) and Chicago Cubs (1911).
February 11 – Jimmy Knowles, 55, Canadian infielder who .241 in 357 games with six different teams in two leagues between 1884 and 1892.
March 6 – Pembroke Finlayson, 23, who pitched from 1908 through 1909 for the Brooklyn Superbas of the National League.
March 9 – Doc Amole, 33, National League pitcher for the Baltimore Orioles (1897) and Washington Senators (1898).
March 22 – Ed Kenna, 34, pitcher for the 1902 Philadelphia Athletics of the American League.
March 25 – Harry Keener, 40, pitcher who posted a 3–11 record and a 5.88 ERA for the 1896 Philadelphia Phillies.
April 17 – Ace Stewart, 43, second baseman for the 1895 Chicago Colts of the National League.
April 18 – Hank Gehring, 31, pitcher who posted a 3–7 record and a 3.91 ERA for the Washington Senators from 1907 to 1908.
April 20 – Sam Barkley, 53, American Association second baseman who played from 1884 through 1889 for the Toledo Blue Stockings, St. Louis Browns, Pittsburgh Alleghenys and Kansas City Cowboys.
April 28 – Josh Bunce, 64, left fielder for the 1877 Brooklyn Hartfords of the National League.
May 7 – Gus Alberts, 51, third baseman/shortstop for the Blues/Brewers/Nationals/Alleghenys from 1884 to 1891.
June 11 – Leonidas Lee, 51, outfielder for the 1877 St. Louis Brown Stockings of the National League.
June 29 – Harry Lyons, 46, outfielder who hit .234 and stole 120 bases in four different leagues with the Giants, Broncos, Browns and Quakers between 1887 and 1893.
August 6 – Dick Van Zant, 47, third baseman for the 1888 Cleveland Blues of the American Association.
August 10 – Ed Sales, 51, for the 1890 Pittsburgh Alleghenys of the National League.
August 15 – Lou Polchow, 32, pitcher for the 1902 Cleveland Bronchos of the American League.
September 5 – Tug Arundel, 50, catcher who played with four teams in two leagues from 1882 to 1888.
September 7 – Bugs Raymond, 30, pitcher who posted a 45–57 record and a 2.49 ERA in 136 games for the Tigers, Cardinals and Giants between 1904 and 1911.
September 15 – Al Barker, 73, who pitched one game for 1871 Rockford Forest Citys of the National Association.
September 26 – Cherokee Fisher, 67, star pitcher before and after the official beginning of professional baseball, known for his blazing fastball, who led the National Association in 1872 with a .909 W-L% and a 1.80 ERA.
October 1 – Bill Boyd, 59, National Association IF/OF/P and manager between the 1872 and 1875 seasons.
October 4 – George Knight, 56, pitcher for the 1875 New Haven Elm Citys of the National Association.
October 6 – Bill Finley, 49, National League catcher/outfielder for the 1886 New York Giants.
October 8 – Heinie Heitmuller, 29, outfielder who played from 1909 to 1910 for the Philadelphia Athletics.
October 10 – Bill Tobin, 58, National League third baseman for the Troy Trojans and Worcester Ruby Legs during the 1880 season.
October 20 – John Skopec, 32, American League pitcher for the Chicago White Sox (1901) and Detroit Tigers (1903).
October 21 – Charlie Waitt, 59, outfielder/first baseman for the Orioles/Browns/White Stockings/Quakers from 1875 to 1883.
October 24 – Piggy Ward, 45, OF/IF who hit .286 with 172 runs and 90 RBI in 221 games with the Senators/Orioles/Reds/Quakers/Pirates from 1883 to 1894.
November 1 – Ed Green, 52, pitcher/infielder for the 1890 Philadelphia Athletics of the American Association.
November 4 – Frank Murphy, 36, National League OF/IF who hit a combined .219 average in 80 games for the Boston Beaneaters and New York Giants in 1901.
November 8 – Cupid Childs, 45, second baseman for the Spiders/Orphans/Stars/Perfectos/Quakers from 1888 to 1901, a .306 career hitter with 1214 hits, who topped the American Association in doubles (1890) and the National League in runs (1892), while ranking third all-time in walks (991) upon retirement.
November 11 – John Rainey, 48, OF/IF for the New York Giants of the National League (1887) and the Buffalo Bisons of the Players League (1890).
November 15 – Dennis O'Neill, 45, first baseman for the 1893 St. Louis Browns of the National League.
November 26 – John T. Brush, 67, owner of the New York Giants from 1890 until the time of his death, who also owned the Indianapolis Hoosiers in the late 1880s and the Cincinnati Reds from 1891 to 1902.
November 27 – Fred Corey, 57[?], 3B/P/OF who posted a 27–46 record and hit a .246 average for the Providence Grays, Worcester Ruby Legs and Philadelphia Athletics between 1878 and 1885.
December 12 – Jim Green, 58, third baseman for the 1884 Washington Nationals of the Union Association.
December 21 – Jim Conway, 54, American Association pitcher who posted a 22–29 record and a 3.64 ERA in 56 games with the Brooklyn Atlantics (1884), Philadelphia Athletics (1885) and Kansas City Cowboys (1889).
December 21 – Jim Gilman, 42, third baseman the 1893 Cleveland Spiders of the National League.
December 22 – Ed Kennedy, 51, third baseman for the Cincinnati Outlaw Reds of the Union Association in 1884.
December 31 – Charlie Sprague, 48, pitcher who went 10–7 with a 4.51 ERA in three seasons with the Chicago White Stockings (1887), Cleveland Spiders (1889) and Toledo Maumees (1890).