ACCN1

Acid-sensing (proton-gated) ion channel 2
Identifiers
Symbols	ASIC2; ACCN; ACCN1; ASIC2a; BNC1; BNaC1; MDEG; hBNaC1
External IDs	OMIM: 601784 MGI: 1100867 HomoloGene: 90965 IUPHAR: ChEMBL: 1628467 GeneCards: ASIC2 Gene
Gene Ontology Molecular function • protein binding • ligand-gated sodium channel activity Cellular component • plasma membrane • integral to plasma membrane Biological process • synaptic transmission • central nervous system development • peripheral nervous system development • monovalent inorganic cation transport • ion transmembrane transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	40	11418
Ensembl	ENSG00000108684	ENSMUSG00000020704
UniProt	Q16515	Q78E63
RefSeq (mRNA)	NM_001094	XM_001001839
RefSeq (protein)	NP_001085	XP_001001839
Location (UCSC)	Chr 17: 31.34 – 32.5 Mb	Chr 11: 80.7 – 81.78 Mb
PubMed search	[1]	[2]

Amiloride-sensitive cation channel 1, neuronal is a protein that in humans is encoded by the ACCN1 gene.

Function

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.

See also

• Acid-sensing ion channel

Further reading

• Price MP, Snyder PM, Welsh MJ (1996). "Cloning and expression of a novel human brain Na+ channel.". J. Biol. Chem. 271 (14): 7879–82. doi:10.1074/jbc.271.14.7879. PMID 8626462. 
• Waldmann R, Champigny G, Voilley N et al. (1996). "The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans". J. Biol. Chem. 271 (18): 10433–6. doi:10.1074/jbc.271.18.10433. PMID 8631835. 
• García-Añoveros J, Derfler B, Neville-Golden J et al. (1997). "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels". Proc. Natl. Acad. Sci. U.S.A. 94 (4): 1459–64. doi:10.1073/pnas.94.4.1459. PMC 19813. PMID 9037075. 
• Bassilana F, Champigny G, Waldmann R et al. (1997). "The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties". J. Biol. Chem. 272 (46): 28819–22. doi:10.1074/jbc.272.46.28819. PMID 9360943. 
• Babinski K, Catarsi S, Biagini G, Séguéla P (2000). "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+". J. Biol. Chem. 275 (37): 28519–25. doi:10.1074/jbc.M004114200. PMID 10842183. 
• Duggan A, Garcia-Anoveros J, Corey DP (2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons". J. Biol. Chem. 277 (7): 5203–8. doi:10.1074/jbc.M104748200. PMID 11739374. 
• Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Price MP, Thompson RJ, Eshcol JO et al. (2005). "Stomatin modulates gating of acid-sensing ion channels". J. Biol. Chem. 279 (51): 53886–91. doi:10.1074/jbc.M407708200. PMID 15471860. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Saugstad JA, Roberts JA, Dong J et al. (2005). "Analysis of the Membrane Topology of the Acid-sensing Ion Channel 2a". J. Biol. Chem. 279 (53): 55514–9. doi:10.1074/jbc.M411849200. PMC 2928846. PMID 15504740. 
• Vila-Carriles WH, Kovacs GG, Jovov B et al. (2006). "Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells". J. Biol. Chem. 281 (28): 19220–32. doi:10.1074/jbc.M603100200. PMID 16704974. 
• Chai S, Li M, Lan J et al. (2007). "A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a". J. Biol. Chem. 282 (31): 22668–77. doi:10.1074/jbc.M703624200. PMID 17548344. 
• Joch M, Ase AR, Chen CX et al. (2007). "Parkin-mediated Monoubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels". Mol. Biol. Cell 18 (8): 3105–18. doi:10.1091/mbc.E05-11-1027. PMC 1949385. PMID 17553932.