Amiloride-sensitive cation channel 4 also known as amiloride-sensitive cation channel 4, neuronal (ACCN4) or amiloride-sensitive cation channel 4, pituitary or acid-sensing ion channel 4 (ASIC4) is a membrane proteinthat in humans is encoded by the ACCN4gene. The ASIC4 protein is a member of the acid-sensing ion channel family that is expressed in the pituitary gland and other parts of the brain. ASIC4 may have lost its ion transport function1 but play a regulatory role through interactions with other members of the family2 or other proteins.34
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC.4
^Chen, X.; Polleichtner, G.; Kadurin, I.; Grunder, S. (2007). "Zebrafish Acid-sensing Ion Channel (ASIC) 4, Characterization of Homo- and Heteromeric Channels, and Identification of Regions Important for Activation by H+". Journal of Biological Chemistry282 (42): 30406–30413. doi:10.1074/jbc.M702229200. PMID17686779.
^Donier, E.; Rugiero, F.; Jacob, C.; Wood, J. N. (2008). "Regulation of ASIC activity by ASIC4 new insights into ASIC channel function revealed by a yeast two-hybrid assay". European Journal of Neuroscience28 (1): 74–86. doi:10.1111/j.1460-9568.2008.06282.x. PMID18662336.
Donier E, Rugiero F, Jacob C, Wood JN (2008). "Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay.". Eur. J. Neurosci.28 (1): 74–86. doi:10.1111/j.1460-9568.2008.06282.x. PMID18662336.
Gründer S, Geissler HS, Bässler EL, Ruppersberg JP (2000). "A new member of acid-sensing ion channels from pituitary gland.". Neuroreport11 (8): 1607–11. PMID10852210.
Gründer S, Geisler HS, Rainier S, Fink JK (2001). "Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia.". Eur. J. Hum. Genet.9 (9): 672–6. doi:10.1038/sj.ejhg.5200699. PMID11571555.