AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2gene.123
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene.3
^Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Oct 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J Biol Chem273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID9733768.
Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris)19 (1): 100–6. doi:10.1051/medsci/2003191100. PMID12836198.
Kirchhausen T, Davis AC, Frucht S et al. (1991). "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast". J. Biol. Chem.266 (17): 11153–7. PMID2040623.
Bresnahan PA, Yonemoto W, Ferrell S et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". Curr. Biol.8 (22): 1235–8. doi:10.1016/S0960-9822(07)00517-9. PMID9811606.
Greenberg M, DeTulleo L, Rapoport I et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol.8 (22): 1239–42. doi:10.1016/S0960-9822(07)00518-0. PMID9811611.
Janvier K, Craig H, Hitchin D et al. (2003). "HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes". J. Biol. Chem.278 (10): 8725–32. doi:10.1074/jbc.M210115200. PMID12486136.