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The plane left Osaka International Airport in Itami at 19:13. At approximately 20:20 it arrived at Matsuyama Airport and was cleared to land on runway 31. On its final approach, the plane was higher than normal and touched down 460 metres beyond the runway threshold. The plane continued on the ground for 170 metres before taking off again for a go-around. The plane reached a height of 70-100 metres, turned left, lost altitude, and crashed into the Seto Inland Sea at approximately 20:30. The reason for the loss of altitude that caused the crash was never determined.
The flight number NH533 is still used on flights today from Tokyo Haneda to Takamatsu Airport.