Calcium-activated potassium channel
This family of ion channels is, for the most part, activated by intracellular Ca2+ and contains 8 members. However, some of these channels (the KCa4 and KCa5 channels) are responsive instead to intracellular Na+ and Cl-. Furthermore, the KCa1 family is both Ca2+- and voltage-activated, further complicating the description of this family. The KCa channel α subunits have six transmembrane segments similar to the KVs, except KCa1, in which the N-terminus makes a seventh pass across the membrane to end up outside the cell. The α subunits make homo- and hetero-tetrameric complexes.
Below is a list of the 8 known calcium-activated potassium channel grouped according to sequence homology of transmembrane hydrophobic cores:1
- Calcium-Activated Potassium Channels at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Calcium-Activated Potassium Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.