DNM3

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Dynamin 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DNM3 ; KIAA0820; MGC70433
External IDs OMIM611445 MGI1341299 HomoloGene22906 GeneCards: DNM3 Gene
EC number 3.6.5.5
RNA expression pattern
PBB GE DNM3 209839 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26052 103967
Ensembl ENSG00000197959 ENSMUSG00000040265
UniProt Q9UQ16 Q8BZ98
RefSeq (mRNA) NM_001136127 NM_001038619
RefSeq (protein) NP_001129599 NP_001033708
Location (UCSC) Chr 1:
171.81 – 172.39 Mb
Chr 1:
161.98 – 162.48 Mb
PubMed search [1] [2]

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene.12 The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding.3 DNM3 is upregulated in Sézary's syndrome.4

References

  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485. 
  2. ^ "Entrez Gene: DNM3 dynamin 3". 
  3. ^ Orth JD, McNiven MA (February 2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701. 
  4. ^ Booken N, Gratchev A, Utikal J, Weiss C, Yu X, Qadoumi M, Schmuth M, Sepp N, Nashan D, Rass K, Tüting T, Assaf C, Dippel E, Stadler R, Klemke CD, Goerdt S (February 2008). "Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3". Leukemia 22 (2): 393–9. doi:10.1038/sj.leu.2405044. PMID 18033314. 

Further reading








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