|Jmol-3D images||Image 1|
|Molar mass||318.02 g/mol|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
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Dichlorodiphenyldichloroethylene (DDE) is a chemical compound formed by the loss of hydrogen chloride (dehydrohalogenation) from DDT, of which it is one of the more common breakdown products.1 DDE is fat soluble which tends to build up in the fat of animals. Due to its stability in fat, DDE is rarely excreted from the body, and body levels tend to increase throughout life. The major exception is the excretion of DDE in breast milk, which delivers a substantial portion of the mother's DDE burden to the young animal or child.citation needed
DDE and its parent, DDT, are reproductive toxicants for certain birds species, and major reasons for the decline of the bald eagle,2 brown pelican3 peregrine falcon, and osprey.4 These compounds cause egg shell thinning in susceptible species, which leads to the birds’ crushing their eggs instead of incubating them, due to the latter’s lack of resistance.5 Birds of prey, waterfowl, and song birds are more susceptible to eggshell thinning than chickens and related species, and DDE appears to be more potent than DDT.4
The biological mechanism for the thinning is not entirely known, but it is believed that p,p'-DDE impairs the shell gland's ability to excrete calcium carbonate onto the developing egg.46789 Multiple mechanisms may be at work, or different mechanisms may operate in different species.4 Some studies have shown that although DDE levels have fallen dramatically, eggshell thickness remains 10–12 percent thinner than before DDT was first used.10
Some studies have indicated that DDE is an endocrine disruptor11 and contributes to breast cancer, but more recent studies provide strong evidence that there is no relationship between DDE exposure and breast cancer.12 What is more clear is that DDE is a weak antiandrogen.13
Animal studies show that organochlorine pesticides—such as DDE—are neurotoxic, cause oxidative stress, and damage the brain's dopaminergic system.14
- ATSDR - Public Health Statement: DDT, DDE, and DDD
- Stokstad, E (2007). "Species conservation. Can the bald eagle still soar after it is delisted?". Science 316 (5832): 1689–90. doi:10.1126/science.316.5832.1689. PMID 17588911.
- "Endangered and Threatened Wildlife and Plants; 12-Month Petition Finding and Proposed Rule To Remove the Brown Pelican (Pelecanus occidentalis) From the Federal List of Endangered and Threatened Wildlife; Proposed Rule," Fish and Wildlife Service, U.S. Department of the Interior, February 20, 2008. 73 F.R. 9407
- ATSDR - Toxicological Profile: DDT, DDE, DDD
- California Wild Spring 1994 - Peregrine Falcons
- Recovery Plan for the California Condor, U.S. Fish and Wildlife Service, April 1996, page 23
- DDE concentration and percent eggshell thinning in Double-crested Conmorant eggs(North Channel, Lake Huron, Ont.)
- Guillette, Louis J., Jr. (2006). "Endocrine Disrupting Contaminants" (PDF). Retrieved 2007-02-02.
- Lundholm, C.E. (1997). "DDE-Induced eggshell thinning in birds". Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 118 (2): 113–28. doi:10.1016/S0742-8413(97)00105-9. PMID 9490182.
- Division of Environmental Quality
- Chemical fact sheet: Organochlorine - The Breast Cancer Fund
- Questions about Endocrine Disruptors
- Longnecker, M. P.; Gladen, B. C.; Cupul-Uicab, L. A.; Romano-Riquer, S. P.; Weber, J.-P.; Chapin, R. E.; Hernandez-Avila, M. (2007). "In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México". American Journal of Epidemiology 165 (9): 1015–22. doi:10.1093/aje/kwk109. PMC 1852527. PMID 17272288.
- Pesticide Exposure Linked to Parkinson's, Alzheimer's Disease