Flufenamic acid

Flufenamic acid

Systematic (IUPAC) name
2-{[3-(Trifluoromethyl)phenyl]amino}benzoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	Prescription Only (S4) (AU)
Routes	oral, topical
Pharmacokinetic data
Protein binding	extensively
Metabolism	Hydroxylation, glucuronidation
Half-life	~3 h
Excretion	50% urine, 36% feces
Identifiers
CAS number	530-78-9
ATC code	M01AG03
PubChem	CID 3371
IUPHAR ligand	2447
DrugBank	DB02266
ChemSpider	3254 Y
UNII	60GCX7Y6BH Y
KEGG	D01581 Y
ChEBI	CHEBI:42638 Y
ChEMBL	CHEMBL23588 Y
Chemical data
Formula	C14H10F3NO2
Mol. mass	281.22991 g/mol
SMILES FC(F)(F)c1cc(ccc1)Nc2ccccc2C(=O)O
InChI InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20) Y Key:LPEPZBJOKDYZAD-UHFFFAOYSA-N Y
Physical data
Melt. point	124–125 °C (255–257 °F) resolidification and remelting at 134°C to 136°C
Solubility in water	Practically insoluble in water; soluble in ethanol, chloroform and diethyl ether mg/mL (20 °C)
Y (what is this?)  (verify)

Flufenamic acid, also known as Fluffy or Fluf^{citation needed}, is a non-steroidal anti-inflammatory drug. It is pale yellow crystalline powder.

Flufenamic acid also blocks voltage-gated sodium channels responsible for the depolarising after-potential (DAP) that underlies phasic firing in the phasic firing of magnocellular neurons in the supraoptic and paraventricular nuclei.^{citation needed}