|Fluorine in the periodic table|
|gas: very pale yellow
liquid: bright yellow
solid: transparent (beta), opaque (alpha)
Liquid fluorine at cryogenic temperatures
|Name, symbol, number||fluorine, F, 9|
|Pronunciation||// FLUU-reen, //, //|
|Element category||diatomic nonmetal|
|Group, period, block||17 (halogens), 2, p|
|Standard atomic weight||18.998403163(6)|
|Electron configuration||[He] 2s2 2p51
|Density||(0 °C, 101.325 kPa)
|Liquid density at b.p.||1.5053 g·cm−3|
|Melting point||53.48 K, −219.67 °C, −363.414 °F|
|Boiling point||85.03 K, −188.11 °C, −306.604 °F|
|Triple point||53.48 K, 904 kPa|
|Critical point||144.41 K, 5.17244 MPa|
|Heat of vaporization||6.512 kJ·mol−1|
|Molar heat capacity||(Cp) (21.1 °C) 313 J·mol−1·K−1
(Cv) (21.1 °C) 233 J·mol−1·K−1
|Electronegativity||3.981 (Pauling scale)|
|1st: 16815 kJ·mol−1|
|2nd: 33745 kJ·mol−1|
|3rd: 61475 kJ·mol−1|
|Covalent radius||646 pm|
|Van der Waals radius||1357 pm|
alpha state (low-temperature)8
|Magnetic ordering||diamagnetic (−1.2×10−4 (SI)910)|
|Thermal conductivity||0.0259111 W·m−1·K−1|
|CAS registry number||7782-41-41|
|Naming||after the mineral fluorite, itself named after Latin fluo (to flow, in smelting)|
|Discovery||André-Marie Ampère (1810)|
|First isolation||Henri Moissan1 (June 26, 1886)|
|Named by||Humphry Davy|
|Most stable isotopes|
|Main article: Isotopes of fluorine|
Fluorine is an extremely reactive and poisonous elemental gas with a pale yellow appearance. It is composed of diatomic molecules, has an atomic number of 9, and is the lightest of the halogens and most electronegative of the elements. Fluorine is the 24th most abundant element in the known universe and the 13th most abundant within the Earth's crust. It has a rich chemistry, forming compounds with nearly all other elements, including some of the noble gases.
The primary mineral source of fluorine, fluorite (calcium difluorine more commonly known as calcium fluoride, CaF
2), was first described in 1529. Trace amounts of F2 are also found in the same calcium fluoride minerals.13 At that time the Latin verb fluo, meaning "flow", became associated with fluorite rocks because they were added to metal ores to lower their melting points during smelting. First suggested as a chemical element in 1811, fluorine proved to be difficult and dangerous to separate from its compounds; several early experimenters were killed or badly hurt in their attempts at doing so. In 1886, French chemist Henri Moissan succeeded in isolating elemental fluorine using low temperature electrolysis, a process still used for the modern industrial production of fluorine.
Because of the expense of refining the pure element, nearly all commercially used fluorine remains in compound form throughout its processing. About half of mined fluorite is used directly in steel-making. The other half is converted to hydrogen fluoride, a dangerous acid that is the precursor to many fluorochemicals. The main use of hydrogen fluoride is in the synthesis of various organic fluorides and in cryolite, an inorganic material critical to aluminium refining. Organic fluorides have very high chemical and thermal stability; their largest market segments are in refrigerant gases and—in the form of polytetrafluoroethylene (Teflon)—electrical insulation and cookware. Modern pharmaceuticals such as atorvastatin (Lipitor) and fluoxetine (Prozac) contain fluorine. The fluoride ion, when directly applied to teeth, reduces decay; for this reason it is used in toothpaste and water fluoridation. The largest current end use of free fluorine, uranium enrichment, began in World War II during the Manhattan Project. Global fluorochemical sales amount to over US$15 billion a year.
Fluorocarbon gases are generally greenhouse gases with warming potentials 100 to 10,000 times that of carbon dioxide. Sulfur hexafluoride–an insulating gas used in electrical plants–exhibits an even stronger effect, at about 20,000 times the global-warming potential of carbon dioxide. Organofluorines endure in the environment due to the strength of the carbon–fluorine bond; the potential health impact of the most persistent of these compounds is unclear. While a few plants and bacteria synthesize organofluorine poisons for defense against herbivores, fluorine has no metabolic role in mammals.
- 1 Characteristics
- 2 Occurrence
- 3 Compounds
- 4 History
- 5 Industry and applications
- 6 Production of fluorine gas
- 7 Environmental concerns
- 8 Biological aspects
- 9 Fluorine-related hazards
- 10 See also
- 11 Notes
- 12 Sources
The difluorine bond is relatively weak, with a bond energy much less than that found in Cl
2 or Br
2 and similar to the easily cleaved oxygen–oxygen bonds of peroxides.1415 For this reason, elemental fluorine easily dissociates to react with other atoms. On the other hand, bonds to non-fluorine atoms are very strong because of fluorine's high electronegativity. Both the easy dissolution of difluorine and its strong bonding to other atoms make fluorine extremely reactive.15 Many substances that are generally regarded as unreactive—such as powdered steel, glass fragments, and asbestos fibers—are readily consumed by cold fluorine gas. Wood and even water burn with flames when subjected to a jet of fluorine, without the need for a spark.216
|Bright flames during fluorine reactions|
|Fluorine reacting with caesium|
Reactions of elemental fluorine with metals require varying conditions. The alkali metals, such as sodium, react explosively. The alkaline earth metals, such as calcium, react somewhat less dramatically. Most of the remaining metals—such as aluminium, iron, and copper—must be powdered to overcome passivation (protective metal fluoride layers formed in the initial exposure).15 The noble metals (gold, platinum, and the like) react least readily, requiring pure fluorine gas at 300–450 °C.17
The metalloids (boron, silicon, germanium, arsenic, antimony and tellurium), and some of the solid nonmetals (sulfur, phosphorus and selenium) burn with a flame in room temperature fluorine.1819 Hydrogen sulfide and sulfur dioxide combine readily with fluorine; the latter reaction can be explosive. Sulfuric acid reacts much more sluggishly.18
Fluorine reacts explosively with hydrogen in a manner similar to that of the alkali metals.20 Carbon, as lamp black, reacts with fluorine at room temperature to yield fluoromethane. Above 400°C, graphite reacts with fluorine to make a varying-composition solid called "carbon monofluoride". At higher temperatures, gaseous fluorocarbons start to be produced and the reaction can become explosive.21 Carbon dioxide and carbon monoxide react with fluorine at room temperature or just above.22 Organic chemicals, such as paraffins, react strongly when exposed to fluorine.23 Even fully halogenated organic molecules, such as the normally incombustible carbon tetrachloride, can explode.24 Nitrogen, with its very strong triple bonds, requires an electric discharge and very high temperatures to react with fluorine even though the end product, NF3, is quite stable.25 Ammonia (NH3) can react explosively with fluorine.2627 Oxygen does not normally react, but can be combined with fluorine under an electric discharge at low pressures and temperatures. The products tend to be unstable and separate back into fluorine and oxygen when heated.282930 The other halogens react readily with fluorine,31 as does the heavy noble gas radon.32 The lighter noble gases xenon and krypton react directly with fluorine under special conditions.33
Fluorine is highly toxic. Its immediately dangerous to life or health concentration is 25 ppm (hydrogen cyanide, in contrast, is 50 ppm).35 Above a concentration of 25 ppm, it causes significant irritation while attacking the eyes, airways, and lungs and affecting the liver and kidneys. At a concentration of 100 ppm, human eyes and noses are seriously damaged.36 Inhalation of 1,000 ppm fluorine will cause death in minutes37 (whereas for hydrogen cyanide a concentration of only 270 ppm is required).38
At room temperature, fluorine is a gas composed of diatomic molecules.2 Though sometimes described as yellow-green, pure fluorine is actually a very pale yellow.39 It has a characteristic pungent odor that is noticeable in concentrations as low as 20 ppb.40 Fluorine condenses to a bright yellow liquid at −188 °C, which is near the condensation temperatures of oxygen and nitrogen.41
Fluorine has two solid forms: beta-fluorine and alpha-fluorine. The beta-phase crystallizes at −220 °C and is transparent and soft. It has a disordered cubic structure that is the same as that of solid oxygen when first crystallized.41note 1 With further cooling to −228 °C, fluorine undergoes a solid–solid phase transition into a form called alpha-fluorine, this being opaque and hard. It has a monoclinic structure featuring close-packed, shingled layers of molecules. The phase change from beta- to alpha-fluorine releases more energy than the melting point transition, and can be violent.note 2845 Solid fluorine is unlike the other halogens (chlorine, bromine, and iodine), all of which have orthorhombic crystalline structures.845
A neutral fluorine atom has nine electrons, one fewer than neon. The electronic configuration is 1s22s22p5: a filled inner shell of two electrons and an unfilled outer shell containing seven (one short of being filled). The outer electrons do not offer much shielding from the nucleus. They therefore experience a high effective nuclear charge of seven (nine minus two), which affects the physical properties of the atom.1
Removal of electrons from neutral atoms is very difficult; fluorine's ionization energy (the energy required to remove an electron) is higher than that of any other element except neon and helium.46 Instead, fluorine exhibits a very strong preference for capturing one more electron to achieve the filled-shell electron configuration of the noble gas neon: 1s22s22p6.1 Fluorine has the highest electronegativity (a relative measure of electron attraction by atoms) among the elements.47 Its electron affinity (the energy released by adding an electron) is higher than that of any element except chlorine.48 Fluorine atoms have a small covalent radius of around 60 picometers; this is similar to the radii of oxygen and neon, its left and right hand periodic table neighbors.note 34950
One stable isotope of fluorine occurs naturally: fluorine-19, which contains ten neutrons.51 Fluorine is thus monoisotopic (having a single stable isotope) and mononuclidic (being found on Earth in only one isotope). Its monoisotopic occurrence makes it useful in uranium enrichment because UF6 molecules differ only in mass due to mass differences between U-235 and U-238. These mass differences are used to separate U-235 and U-238 via diffusion and gas centrifugation.52 Fluorine's mononuclidic (100%) abundance make it well suited to magnetic resonance imaging, since it also has a high nuclear magnetogyric rationote 4 (which translates to exceptional magnetic field sensitivity).54
Seventeen radioisotopes have been synthesized, having mass numbers 14–18 and 20–31.55 The lightest fluorine isotopes, those with mass numbers of 14–16, decay via electron capture. Fluorine-17 and -18 undergo beta plus decay (emission of a positron). All isotopes heavier than fluorine-19 decay by beta minus mode (emission of an electron); some of these also decay by neutron emission. Fluorine-18 is the most stable radioisotope, with a half-life of 109.77 minutes before decaying to oxygen-18.55
For the ninth lightest element, fluorine is unusually rare given the lighter elements tend to be the more common ones. All of the elements from atomic number 6 (carbon) to atomic number 12 (magnesium) are hundreds to thousands of times more common, with the exception of sodium (which is tens of times more common).57 At 400 ppb, fluorine is estimated to be the 24th most common element in the universe.
Fluorine's rarity results from both a low stellar birth rate and rapid destruction. The main fusion reaction sequences of stars (stellar nucleosynthesis) which produce oxygen, carbon, and neon, bypass fluorine. Any fluorine which is nonetheless created is a large target (has a high nuclear cross section) for further fusion—either with hydrogen to form oxygen and helium, or with helium to form neon and hydrogen.5758
The presence of fluorine at all—outside its fleeting existence in stars—is somewhat of a mystery given these fluorine-eliminating reactions.5759 Three theoretical solutions exist. In type II supernovae, atoms of neon could be hit by neutrinos during the explosion and converted to fluorine. In Wolf–Rayet stars (blue stars over 40 times heavier than the Sun), a strong solar wind could blow the fluorine out of the star before hydrogen or helium can destroy it. In asymptotic giant branch stars (a type of red giant), pulses of fusion reactions could result in convection currents lifting fluorine out of the inner star.5759
Fluorine is the thirteenth most common element in the Earth's crust, comprising between 600 and 700 ppm by mass.60 Being so reactive, any free fluorine in the atmosphere of early Earth is likely to have been removed by being bound to surface rocks.6162 It is essentially therefore found only in mineral compounds. Fluorite, fluorapatite, and cryolite are the three most industrially significant compounds.6364
2), also called fluorspar, is the main source of commercial fluorine. It is colorful, common, and can be found worldwide. China supplies over half the world's demand; Mexico is second. The U.S. produced most global fluorite in the early 20th century but its last mine, in Illinois, closed in 1995.6465666768
Fluorapatite (Ca5(PO4)3F) and other apatites are mined in high volumes to produce phosphates for fertilizers. Most of the Earth's fluorine is bound in fluorapatite, but because the fluorine fraction is low (3.5%), it is discarded as waste. Only in the U.S. is there significant recovery: byproducts are used to supply water fluoridation.64
6), the least abundant of the three major fluorine-containing minerals, is a concentrated source of fluorine. It was formerly used directly in aluminium production. The main commercial mine, on the west coast of Greenland, closed in 1987.64
|Major fluorine-containing minerals|
Several other minerals, such as the gemstone topaz, include fluorine among their constituents. Fluorine is not significant in seawater or brines, unlike the other halides, because the alkaline earth fluorides (for example, CaF2, MgF2) precipitate out of water.64 Commercially insignificant quantities of organofluorines have been observed in volcanic eruptions and in geothermal springs. Their ultimate origin, whether from biological sources or geological formation, is unclear.69
The possibility of small amounts of gaseous fluorine within crystals has been debated for many years. When crushed, one form of fluorite (antozonite) has a smell suggestive of fluorine.7071 In 2012, a study reported detection of trace quantities (0.04% by weight) of diatomic fluorine in antozonite. It was suggested that radiation from small amounts of uranium within the crystals had caused the free fluorine defects.71
Fluorine has a rich chemistry encompassing compounds formed with metals, nonmetals, and even noble gases, as well as a diverse set of organic compounds; note 572 Its common oxidation state is −1.note 6 Because of its attraction for electrons, fluorine forms many ionic compounds. Covalent bonds involving fluorine are polar and are almost always, within molecules, single bonds.note 77677
The alkali metals form monofluorides that, like the alkali metal chlorides, are very ionic and soluble. They have the same atomic arrangement—the rock salt crystal structure—as sodium chloride.7879 The difluorides of the alkaline earths are also very ionic but are generally very insoluble.80 Beryllium difluoride is an exception: it exhibits some covalent character, is water soluble, and has a structure similar to SiO2 (quartz).81 Trifluorides are formed by many metals, particularly the rare earths, and are generally ionic.828384
The tetrafluorides represent a transition from ionic to covalent bonding. Zirconium and hafnium,8586 along with several actinides,87 form high melting, ionic tetrafluorides.88note 8 On the other hand, the tetrafluorides of titanium,91 vanadium,92 and niobium are polymeric.93 They melt or decompose below about 350 °C.94 The pentafluorides are even more covalently bonded, forming low dimensionality polymers or oligomeric molecules (clusters).959697
A total of thirteen metal hexafluorides have been characterized, all forming octahedredral molecules.note 9 All are volatile solids except molybdenum hexafluoride and rhenium hexafluoride (which are liquids) and tungsten hexafluoride (a gas).9899100 The only definite metal heptafluoride, that of rhenium, is a low-melting molecular solid. Its structure is a distorted pentagonal bipyramid.101 The higher metal fluorides are very reactive.102
|Progression of structure type with metal charge in the metal fluorides|
|Sodium fluoride, ionic||Bismuth pentafluoride, polymeric||Rhenium heptafluoride, molecular|
Fluorine combines with hydrogen to make hydrogen fluoride (HF), a compound in which the HF molecules cluster weakly together via hydrogen bonds. Because of this, hydrogen fluoride behaves more like water than HCl (hydrochloric acid).103104105 It boils at a much higher temperature than the heavier hydrogen halides. HF is also fully miscible with water (that is, it dissolves in any proportion), unlike HCl, HBr, or HI.106
Water solutions of hydrogen fluoride are called hydrofluoric acid. This is a chemically weak acid, unlike the other hydrohalic acids (such as hydrochloric) which are all strong.107note 10 Although hydrofluoric acid is weak, it is very corrosive, even attacking glass.109
The binary fluorides of the main group metalloids and nonmetals are generally volatile, covalently bonded molecules that vary greatly in their reactivities. Nonmetals from the third row of the periodic table and below can form fluorides which are hypervalent (that is, they have more bonds than normal).111
Boron trifluoride is a planar molecule in which the boron atom has an incomplete octet (with fewer bonds than normal). It is a weak Lewis acid and readily accepts a Lewis base, such as ammonia, thereby forming adducts (combinations).
The simplest binary compound with carbon is carbon tetrafluoride, an inert tetrahedral molecule.note 11 The atoms below carbon, silicon and germanium, also form tetrahedral tetrafluorides:112 these are Lewis acids.113114
Nitrogen and its congeners form trifluorides of increasing reactivity and Lewis basicity. Nitrogen trifluoride is stable against hydrolysis and is not a Lewis base.115 The atoms below nitrogen form trifluorides that are weak Lewis bases and are more reactive as the atom becomes heavier.115 Pentafluorides are formed by phosphorus, arsenic, and antimony. They are even more reactive than the respective trifluorides; antimony pentafluoride is the strongest Lewis acid of all charge-neutral compounds.11695117
The chalcogens (elements making up the oxygen group) form a variety of fluorides. Unstable difluorides are known for oxygen (the only compound in which oxygen is at a formal oxidation state +2) as well as for sulfur and selenium. Tetrafluorides and hexafluorides are known for sulfur, selenium, and tellurium. They tend to be more stable with more fluorine atoms and a lighter central atom: sulfur hexafluoride (SF6) is extremely inert.118119
The well-characterized heavier halogens (chlorine, bromine, and iodine) all form mono-, tri-, and pentafluorides: XF, XF3, and XF5. For XF7, only iodine heptafluoride is known.120 Many of the halogen fluorides are powerful fluorinators (sources of fluorine atoms). Chlorine trifluoride readily fluorinates asbestos and refractory oxides; its use in industry requires precautions similar to those for fluorine gas.121122
The noble gases are generally non-reactive because they have complete electron shells. Until the 1960s, no chemical bond with a noble gas was known. In 1962, Neil Bartlett reported the synthesis of xenon hexafluoroplatinate, the first noble gas compound.124 Since then, xenon difluoride, xenon tetrafluoride and xenon hexafluoride have been isolated, as well as various oxyfluorides.125126 Krypton, the lighter homolog of xenon, forms a difluoride and a few more complicated fluorine containing compounds.127 Radon, the heavier homolog of xenon, reacts readily with fluorine to form a solid, which is thought to be radon difluoride.128129
Some of the lightest noble gases form binary fluorides of only exceptionally limited stability. Argon reacts in extreme conditions with hydrogen fluoride to form argon fluorohydride.33 Helium and neon do not form any time-stable fluorides, but helium fluorohydride has been observed for milliseconds at extremely high pressure and low temperature.130 Neon is considered even less reactive than helium, and no fluorides have been even momentarily observed.131
The carbon–fluorine chemical bond is the strongest bond in organic chemistry;132 organofluorines are subsequently very stable.133 With a few exceptions, the C–F bond does not exist in nature, meaning the entire field is essentially "handmade",134 with research in particular areas tending to be driven by the commercial value of applications. The range of organofluorine compounds is diverse, reflecting the inherent complexity of organic chemistry.135
Monofluoroalkanes (alkanes with one hydrogen replaced with fluorine) have properties similar to unfluorinated alkanes. They are soluble in many nonpolar solvents and have some chemical and thermal instability. As more fluorine atoms are substituted for hydrogen atoms, the properties change: solubility in hydrocarbons decreases and stability increases. Also, melting and boiling points decrease, while density goes up.136
When all hydrogen atoms are replaced with fluorine atoms to make perfluorocarbons ("per" meaning maximum),note 12 a great difference becomes apparent: such compounds are extremely stable, and they are only subject to attack at standard conditions by sodium in liquid ammonia. They are also very insoluble, with few organic solvents capable of dissolving them.136
Perfluorinated compound is a term for hydrocarbons that are fully fluorinated but which also have a functional group (a small non-hydrocarbon part of the molecule).note 13138 Often this is a carboxylic acid (-CO2H) group. Perfluorinated compounds exhibit many perfluorocarbon properties such as inertness, stability, non-wetting by water and oils, and slipperiness.139 The functional group is however available for reactions. It may also help the molecule to adhere to surfaces or behave as a surfactant (a soap-like mixture).140 Fluorosurfactants can lower the surface tension of water below that achievable with hydrocarbon-based surfactants. Industry practice is to also regard fluorotelomers‒perfluorinated compounds with fluorinated backbones, but also a few non-fluorinated carbons (typically two) near the functional group‒as perfluorinated.139
As with small molecules, replacing hydrogen with fluorine in a polymer increases chemical stability and reduces flammability. Melting points are typically much higher than in the corresponding hydrocarbon polymers.141
The simplest fluoroplastic is PTFE (polytetrafluoroethylene, DuPont brand Teflon), which is a simple linear chain polymer with the repeating structural unit: –CF2–. It has no hydrogen atoms and is the perfluoro analog of PE (polyethylene, structural unit: –CH2–). PTFE, as expected for a perfluorocarbon, has a much higher chemical and thermal stability than that of polyethylene. However, its very high melting point makes it difficult to fashion into parts.142
Various PTFE derivatives have lower maximum usage temperatures but have the benefit of being more melt-processable. FEP (fluorinated ethylene propylene) is structurally similar to PTFE but has some fluorine atoms replaced with –CF3 groups. PFA (perfluoroalkoxy) has some fluorine atoms replaced with –OCF3 groups.142 Nafion is a structurally complicated polymer. It has a PTFE-like backbone, but also contains side chains of perfluoro ether that end in sulfonic acid (–SO2OH) groups.144145
There are other fluoroplastics that are not perfluorinated; these contain some C-H groups. PVDF (that is, polyvinylidene fluoride, with the structural unit –CF2CH2–) has half the fluorine atoms of PTFE. PVF (polyvinyl fluoride, structural unit: –CH2CHF–) has even less. Despite this, it still has many of the properties of fully fluorinated polymers.146
Fluorite, the main source mineral of fluorine, was described in 1529 by Georgius Agricola, who related its use as a flux—an additive that helps lower melting temperature during smelting.147148note 14 Agricola, the "father of mineralogy", invented several hundred new terms in his Latin works describing 16th-century industry. For fluorite rocks (schöne Flüsse in the German of the time), he created the Latin noun fluorés, from fluo (flow). The name for the mineral later evolved to fluorspar (still commonly used) and then to fluorite.15265153
Hydrofluoric acid was used as a glass-etching agent from the 1720s, and perhaps as early as 1670.note 15 Andreas Sigismund Marggraf made the first scientific report on its preparation in 1764 when he heated fluorite with sulfuric acid; the resulting solution corroded its glass container.156157 Swedish chemist Carl Wilhelm Scheele repeated this reaction in 1771, recognizing the product as an acid, which he called "fluss-spats-syran" (fluor-spar-acid).157158
In 1810, French physicist André-Marie Ampère suggested that hydrofluoric acid was a compound of hydrogen with an unknown element, analogous to chlorine.159 Fluorite was then shown to be mostly composed of calcium fluoride.155 Sir Humphry Davy originally suggested the name fluorine, taking the root from the name of "fluoric acid" and the "-ine" suffix, similarly to other halogens. This name, with modifications, came to most European languages, although Greek, Russian, and some others (following Ampère's suggestion) use the name ftor or derivatives, from the Greek φθόριος (phthorios), meaning "destructive".160 The New Latin name (fluorum) gave the element its current symbol, F, although the symbol Fl was used in early papers.80note 16
Progress in isolating the element was slowed by the exceptional dangers of generating fluorine; several 19th-century experimenters—the "fluorine martyrs"—were killed or badly hurt while working with hydrofluoric acid.note 17 Initial attempts to isolate the element were hindered by problems obtaining a suitable conducting liquid for electrolysis as well as by the extreme corrosiveness of hydrogen fluoride and of fluorine gas.155161
Edmond Frémy postulated that passing electric current through pure hydrofluoric acid (that is, hydrogen fluoride) might allow the element to be isolated. Previously, hydrogen fluoride was only available in a water solution. Frémy therefore devised a method for producing dry hydrogen fluoride by acidifying potassium bifluoride (KHF2). He discovered, however, that pure hydrogen fluoride would not transmit an electric current.155161162
French chemist Henri Moissan, formerly one of Frémy's students, continued the search. After trying many different approaches, he combined potassium difluoride and dry hydrogen fluoride. The mixture proved capable of conducting electricity, making electrolysis possible. However, rapid destruction of the platinum metal in his electrochemical cells stymied the quest. To continue, Moissan devised a strategy of cooling the reaction to extremely low temperatures, in a special bath, so as to slow the rate of corrosion. Moissan also made equipment that was more corrosion-resistant: containers crafted from a mixture of platinum and iridium (more chemically resistant than pure platinum) with fluorite stoppers.163161 In 1886, Moissan crowned 74 years of effort by many chemists when he isolated elemental fluorine.162164
... in recognition of the great services rendered by him in his investigation and isolation of the element fluorine ... The whole world has admired the great experimental skill with which you have studied that savage beast among the elements.
|Moissan's apparatus, 1887 publication||Henri Moissan, Nobel Prize photo|
In the late 1920s, chlorofluorocarbon refrigerants were tested by researchers from the Frigidaire division of General Motors. In 1930, GM and DuPont formed a joint venture under the name Kinetic Chemicals, with a view to commercializing one such chlorofluorocarbon: Freon-12 (CCl
2). It proved to be a marketplace success, rapidly replacing earlier more toxic refrigerants, and contributing to the growth of the overall market for kitchen refrigerators. By 1949, DuPont had bought out the joint venture and marketed several other Freon molecules.135157166167
In 1938, Teflon ((C2F4)n) was accidentally discovered by a recently hired Kinetic chemist, Roy J. Plunkett. Undertaking research on the possible use of tetrafluoroethylene as a refrigerant, he encountered a mystery. Gas left in a cylinder overnight could not be released the next morning, but the weight of the container had not changed (indicating the gas had not leaked out). Cutting the cylinder open, he found white flakes of an unknown substance. Tests showed it to be polytetrafluoroethylene ('poly-' meaning 'many'). The new polymer was more resistant to corrosion and more stable at high temperatures than any other plastic. By 1941, it was being produced in significant quantities as a result of an accelerated commercialization program.135157166
Large-scale production of elemental fluorine began during World War II. Germany used high-temperature electrolysis to produce tons of chlorine trifluoride, a compound planned for use as an incendiary.168 The Manhattan Project in the U.S. used even more elemental fluorine to make uranium hexafluoride for use in uranium enrichment plants. Because UF6 is about as corrosive as fluorine itself, gaseous diffusion separation plants had to be built with special materials. Nickel was used for the membranes; fluoropolymers such as Teflon were used for seals; and liquid fluorocarbons were used as coolants and lubricants. After the war, the burgeoning nuclear weapons industry drove further development of fluorochemical compounds.169
Fluorite mining, the main source of fluorine, was a growing industry up to 1989 when it peaked at 5.6 million metric tons of ore extracted in that year. Environmental restrictions on the use of chlorofluorocarbons subsequently reduced production, down to 3.6 million tons in 1994. Production has steadily risen since that time. In 2003, it was estimated at 4.5 million tons with a corresponding revenue of US$550 million. Subsequent market research reports estimated 2011 global fluorochemical sales at $15 billion and have predicted production figures over the period 2016‒18 in the range of 3.5 to about 5.9 million tons, with revenue of $20 billion, or more.157170171172173
Mined fluorite is concentrated by flotation separation into two main grades, with about equal production of each. Metspar (60–85% purity) is used almost exclusively for iron smelting. Acidspar (97%+ purity) is mainly converted to hydrogen fluoride, the primary chemical intermediate for the fluorochemical industry.66157174
About 3 kg of metspar-grade fluorite are added to each metric ton of steel. The fluoride ions from CaF2 lower the melt's temperature and viscosity, making it runnier. Metspar is similarly used to produce cast iron and other iron alloys.66175
Most acidspar-grade fluorite is reacted with sulfuric acid to make hydrofluoric acid (HF). Significant direct uses of HF include pickling (cleaning) steel, etching glass, and cracking alkanes in the petrochemical industry.66 Acidspar-grade fluorite is also added to ceramics, enamels, glass fibers, clouded glass, cement, and the outer coating of welding rods.66
One third of HF (one sixth of mined fluorine) is used to make synthetic cryolite (sodium hexafluoroaluminate) and aluminium trifluoride. These compounds are used in the electrolysis of aluminium by the Hall–Héroult process. The fluorides are not reactants in the smelting process, but fluxes that lower the temperature of the melt. They are not consumed in the process and remain available to support smelting. However, over time, small amounts are lost through side reactions with the smelting apparatus and new fluorides must be added. About 23 kg are required for every metric ton of aluminium.66176
Fluorosilicates are the next most significant inorganic fluorides formed from HF. Sodium fluorosilicate is used for water fluoridation; as an intermediate for synthetic cryolite and silicon tetrafluoride; and for the treatment of effluents in laundries.177 Other inorganic fluorides made in large quantities include: cobalt difluoride (for organofluorine synthesis); nickel difluoride (electronics); lithium fluoride (a flux); sodium fluoride (water fluoridation); potassium fluoride (flux); ammonium fluoride (various uses); and magnesium fluoride (antireflective optical coatings).6679178
Organofluoride production consumes over 20% of all mined fluorite and over 40% of hydrofluoric acid. Refrigerant gases are the dominant segment. Fluoropolymers represent less than one quarter the consumption of refrigerant gases in terms of fluorine usage but are growing faster.66179 Fluorosurfactants are molecules used to make clothing and other items water-resistant. They make up a small market segment but generate over US$1 billion in yearly revenue.180
Industrially, production of fluorocarbons relies on indirect methods because the direct reaction of hydrocarbons with fluorine gas can be dangerous at temperatures above −150 °C. Many fluorochemicals are made by halogen exchange reactions: chlorinated hydrocarbons react with hydrogen fluoride to switch out chlorine for fluorine. The reactions are catalyzed, for example, by antimony halides in "Swarts fluorination". Another method is electrochemical fluorination, in which hydrocarbons are electrolyzed in hydrogen fluoride. In the Fowler process, hydrocarbons are reacted with solid carriers of fluorine, notably cobalt trifluoride.135181
Halogenated molecules used in refrigeration are identified by the R-number system, which explains the amount of fluorine, chlorine, carbon, and hydrogen in each molecule.182 The DuPont brand Freon has been colloquially used for these compounds, but brand-neutral terminology uses "R" ("refrigerant") as the prefix.note 1966
Traditionally, chlorofluorocarbons (CFCs) were the predominant class of fluorinated organic chemical. Prominent CFCs included R-11 (trichlorofluoromethane), R-12 (dichlorodifluoromethane), and R-114 (1,2-dichlorotetrafluoroethane). Production of CFCs grew strongly through the 1980s, primarily for refrigeration and air conditioning but also for propellants and solvents. By the early years of the 21st century, production had fallen to less than 10% of the mid-1980s peak, after most countries banned the end use of these chemicals.66
Hydrochlorofluorocarbons (HCFCs) and hydrofluorocarbons (HFCs) serve as replacements for CFC refrigerants; few were commercially manufactured before 1990. More than 90% of fluorine used for organics goes into these two classes, in roughly equal amounts. Prominent HCFCs include R-22 (chlorodifluoromethane) and R-141b (1,1-dichloro-1-fluoroethane). The main HFC is R-134a (1,1,1,2-tetrafluoroethane).66 In response to greenhouse gas concerns, world-wide demand for HFO-1234yf, another HFC, is increasing as it has a global-warming potential that is less than one per cent that of HFC-134a.183
As of about 2006–2007, fluoropolymer volume was estimated at over 180,000 metric tons per year. The corresponding revenue estimate was over US$3.5 billion.184 The 2011 global fluoropolymer market was estimated at slightly under $6 billion in revenue and predicted to grow 6.5% per year through 2016.185 Fluoropolymers are formed by polymerizing free radicals; other hydrocarbon polymerization techniques do not work.141
Polytetrafluoroethylene (PTFE) represents 60–80% of the world's fluoropolymer production on a weight basis.184 The DuPont brand Teflon is sometimes used generically for this substance.187 The largest application is in electrical insulation since PTFE is an excellent dielectric. It is also used in the chemical industry where corrosion resistance is needed: in coating pipes, tubing, and gaskets. Another major use is as architectural fabric in the form of PTFE-coated fiberglass cloth used for stadium roofs. The major consumer application is for non-stick cookware.187
When stretched with a sudden jerk, PTFE film becomes a fine-pored membrane in the form of expanded PTFE (ePTFE). The term "Gore-Tex" is sometimes used generically although this is a specific brand name. ePTFE is used in rainwear, protective apparel, and liquids and gas filters. PTFE can also be formed into fibers which are used in pump packing seals and bag house filters.187
Other fluoropolymers tend to have similar properties to PTFE, which leads to their use in electrical insulation and the chemical process industry. Unlike PTFE, these other fluoropolymers can be melt-processed. This makes them easier to work with as they can be formed into complex shapes, but they are also more expensive than PTFE and have lower thermal stability. Fluorinated ethylene propylene (FEP) is the second most produced fluoropolymer. Films from two different fluoropolymers serve as glass-replacements in solar cells.187188
Fluorinated ionomers (polymers that include charged fragments) are expensive, chemically resistant materials used as membranes in electrochemical cells. Nafion, developed in the 1960s, was the first example and remains the most prominent material in the class. The initial application was as fuel cell material in spacecraft. Since then, this polymer has been transforming the 55 million tons per year chloralkali industry: it is replacing hazardous mercury-based cells with membrane cells. Recently, the fuel cell application has reemerged with efforts to instaill proton exchange membrane (PEM) fuel cells into automobiles.189190191
There are also fluorocarbon-based fire extinguishers.192
Fluorinated surfactants are small organofluorine molecules, principally used for water and stain resistance. As of 2006, yearly revenues for this segment were over US$1 billion. Fluorosurfactants are expensive chemicals, comparable to pharmaceutical chemicals: $200–2000 per kilogram ($90–900 per pound). Scotchgard has been a prominent brand; revenues in 2000 were over $300 million.180193194
Fluorosurfactants make up a very small part of the overall surfactant market, most of which is hydrocarbon-based and much cheaper. Some potential applications (for example, low cost paints) are unable to use fluorosurfactants because of the price impact of compounding in even small amounts of fluorosurfactant. Usage in paints represented a market of only about US$100 million as of 2006.180
For countries with available data, about 17,000 metric tons of fluorine are produced per year. Fluorine is relatively inexpensive, costing about US$5–8 per kilogram when sold as uranium hexafluoride or sulfur hexafluoride. Because of difficulties in storage and handling, the price of fluorine gas is much higher. Processes demanding large amounts of fluorine gas are generally vertically integrated and entail on-site production.195
The largest application for elemental fluorine (up to 7,000 metric tons per year) is in the preparation of uranium hexafluoride, which is used in the production of nuclear fuels. Uranium dioxide is first treated with hydrofluoric acid to produce uranium tetrafluoride. This compound is then further fluorinated by direct exposure to fluorine gas to make the hexafluoride.195 Fluorine's monoisotopic natural occurrence makes it useful in uranium enrichment, in which uranium-235 is separated by diffusion or centrifugation from uranium-238. The difference in mass between uranium hexafluoride molecules arises entirely from the different masses of the two uranium isotopes.662
The second largest application for fluorine gas (about 6,000 metric tons per year) is in the production of sulfur hexafluoride, which is used as a dielectric medium in high voltage transformers and circuit breakers. SF6 gas has a much higher dielectric strength than air and is extremely chemically inert. Switchgear using SF6 has no hazardous polychlorinated biphenyls (PCBs), in contrast to traditional oil-filled devices.196
Several compounds made from elemental fluorine serve the electronics industry. Rhenium and tungsten hexafluorides are used for chemical vapor deposition of thin metal films. Tetrafluoromethane is used for plasma etching.197198199 Nitrogen trifluoride is used for cleaning equipment.66
Some organic fluorides are prepared from elemental fluorine rather than from HF. However, because direct fluorination is usually too hard to control, intermediate strength fluorinators are made from fluorine gas. The halogen fluorides ClF
3, and IF
5 provide gentler fluorination, with a series of strengths, and are easier to handle. Sulfur tetrafluoride is used for making fluorinated pharmaceuticals.66
Modern industrial production of elemental fluorine uses Moissan's process of electrolyzing a mixture of potassium fluoride and hydrogen fluoride, but with an apparatus made of different materials. A steel container acts as the negative electrode, attracting H+ ions and releasing hydrogen gas. A carbon block (similar to that used in aluminium production) acts as the positive electrode, attracting F− ions and releasing fluorine gas. The voltage difference between the electrodes is 8–12 volts.66200
Commercial temperatures are now higher than those used by Moissan. A mixture with the approximate composition KF•2HF melts at 70 °C (158 °F) and is electrolyzed at 70–130 °C. Because HF alone cannot be electrolyzed, the presence of some KF is critical even though it is not consumed in the cell.157201202
Pure fluorine gas may be stored in steel cylinders where the inside surface is passivated, as long as the temperature is kept below 200 °C. Above that temperature, nickel is required.157203 Regulator valves are made of nickel. Fluorine piping is generally made of nickel or Monel (a nickel-copper alloy).204 Care must be taken to passivate all surfaces frequently and to exclude any water or greases. In the laboratory, fluorine gas may be used in glass tubing provided the pressure is low and moisture is excluded.204 Some sources instead recommend systems made of nickel, Monel, and PTFE.205
In 1986, when he was preparing for a conference to celebrate the 100th anniversary of the discovery of fluorine, Karl O. Christe realized that the chemical generation of fluorine ought to be feasible. The main idea was that some metal fluoride anions either did not have neutral counterparts (or had such counterparts that were very unstable) and that acidifying these anions could result in chemical oxidation, rather than formation of the expected molecules. The method involved, which resulted in a high yield of fluorine at atmospheric pressures, was:206
- 2 KMnO4 + 2 KF + 10 HF + 3 H2O2 → 2 K2MnF6 + 8 H2O + 3 O2↑
- 2 K2MnF6 + 4 SbF5 → 4 KSbF6 + 2 MnF3 + F2↑
Christe subsequently commented that the reactants involved 'had been known for more than 100 years and even Moissan could have come up with this scheme.'207 Up until at least 2006, references could still be found in the literature asserting that fluorine was too reactive to be able to be separated from its compounds by chemical means.208
Because they deplete the ozone layer, chlorofluorocarbons (CFCs) and bromofluorocarbons (BFCs) have been strictly regulated via a series of international agreements called the Montreal Protocol. It is the chlorine and bromine from these molecules that cause harm, not the fluorine. Because of the inherent stability of these fully halogenated molecules (which makes them so nonflammable and useful), they are able to attain the upper reaches of the atmosphere before decomposing. At high altitudes, they release chlorine and bromine atoms which attack ozone molecules.210 Predictions are that even after the CFC ban, several generations will be required for these molecules to leave the atmosphere and for the ozone layer to fully recover. Early indications are that the CFC ban is working: ozone depletion has stopped, and recovery has started.211212
Hydrochlorofluorocarbons (HCFCs) are current replacements for CFCs, with about one-tenth the ozone damaging potential (ODP).213 They were themselves originally scheduled for elimination by 2030 in developed nations and 2040 in undeveloped nations, with replacement by hydrofluorocarbons (HFCs) (which have no chlorine and thus zero ODP). In 2003, the U.S. Environmental Protection Agency prohibited production of one HCFC and capped the production of the two others.214 In 2007, a new treaty was signed by almost all nations to move the HCFC phaseout up to 2020.215
Fluorocarbon gases (CFCs, HFCs, and the like) are generally greenhouse gases with about 100 to 10,000 times the potency of carbon dioxide. Sulfur hexafluoride exhibits an even stronger effect, at about 20,000 times the global-warming potential of carbon dioxide.216 A notable outlier is HFO-1234yf, which has a global warming potential (GWP) of only four times that of carbon dioxide, compared with a GWP of 1,430 for HFC-134a, the current industry refrigerant standard. Global demand for, and interest it, HFO-1234yf is increasing in response to greenhouse gas concerns.183
Organofluorines endure in the environment due to the strength of the carbon–fluorine bond. Perfluoroalkyl acids (PFAAs) have attracted particular attention as persistent global contaminants. Because of their acid group, PFAAs are water soluble in low concentrations.217 While there are other PFAAs, the lion's share of environmental research has been done on the two most well-known: perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA).218219220
Trace quantities of PFAAs have been detected worldwide, from polar bears in the Arctic to the global human population. Both PFOS and PFOA have been detected in breast milk and the blood of newborns. A 2013 review showed widely varying amounts of PFAA in different soils and groundwater, with generally higher amounts in areas of more human activity. There was no clear pattern of one chemical dominating, and higher amounts of PFOS were correlated to higher amounts of PFOA.218219221
In the body, PFAAs bind to proteins such as serum albumin. Unlike chlorinated hydrocarbons, PFAAs are not lipophilic (stored in fat). Their tissue distribution in humans is unknown, but studies in rats suggest they are present mostly in the liver, kidneys, and blood. They are not metabolized by the body but are excreted by the kidneys. Dwell time in the body varies greatly by species. Rodents have half-lives of days, while in humans they remain for years.218219223
The potential health impact of PFAAs is unclear. Both PFOA and PFOS in high doses cause cancer and the death of newborns in rodents. However, studies on humans have not been able to establish an impact at current exposure levels.218219223
Less fluorinated chemicals (not perfluorinated compounds) are also detectable in the environment. Because biological systems do not metabolize fluorinated molecules easily, fluorinated pharmaceuticals (often antibiotics and antidepressants) are among the major fluorinated organics found in treated city sewage and wastewater.224 Fluorine-containing agrichemicals are measurable in farmland runoff and nearby rivers.225
Fluorine is not considered to be an essential mineral element for mammals or humans. Small amounts may be beneficial for bone strength, but this has not been definitively established. As there are many environmental sources of trace fluorine, the possibility of "fluorine deficiency" pertains only to artificial diets.226227
Biologically synthesized organofluorines have been found in microorganisms and plants,69 but not in animals.228 The most common example is fluoroacetate. It is used as a defense against herbivores by at least 40 green plants in Africa, Australia and Brazil.229 Other biologically synthesized organofluorines include ω-fluoro fatty acids, fluoroacetone, and 2-fluorocitrate.228 The enzyme adenosyl-fluoride synthase, which makes the carbon–fluorine bond, was isolated in bacteria in 2002.230
Since the mid-20th century, population studies have shown that fluoride reduces tooth decay. The initial hypothesis was that fluoride helped by converting tooth enamel from the mineral hydroxyapatite to the more acid-resistant mineral fluorapatite. However, recent studies showed no difference in the frequency of caries (cavities) amongst teeth that were pre-fluoridated to different degrees. Current thinking is that fluoride prevents cavities primarily by helping teeth–which are in the very early stages of tooth decay–to regrow tooth enamel. In any case, it is only the fluoride that is directly present in the mouth (topical treatment) that prevents cavities; fluoride ions that are swallowed confer no such benefit.231
Water fluoridation is the controlled addition of fluoride to a public water supply to reduce tooth decay.232 It began in the 1940s following studies of children in a region where water was naturally fluoridated. It is now used for about two thirds of the U.S. population on public water systems and for about 6% of people worldwide.233234 Although the best available evidence shows no association with adverse effects other than dental fluorosis, most of which is mild,235 water fluoridation has been contentious for ethical, safety, and efficacy reasons.234 Opposition to water fluoridation exists despite its support by public health organizations.236 The benefits of water fluoridation have lessened recently—presumably because of the availability of fluoride in other forms—but are still measurable, particularly for low-income groups.237 Reviews of the scholarly literature in 2000 and 2007 associated water fluoridation with a significant reduction of tooth decay in children.238
Toothpaste may contain fluorine in the form of sodium fluoride, tin difluoride, or (most commonly) sodium monofluorophosphate. The first fluoride toothpaste was introduced in 1955 in the U.S. Almost all toothpaste in developed countries is now fluoridated, as are many prescription and non-prescription mouthwashes. Fluoride may also be applied to teeth in gels, foams, or varnishes.237239
Fluorine atoms are present in 20% of modern pharmaceuticals.240 Replacing hydrogen with fluorine can protect drugs from degradation by metabolic enzymes and extend their active lifetimes in the body. The introduction of fluorine can alter a molecule's shape so that it binds better to its target protein.240 One pharmaceutical cholesterol-reducer atorvastatin (Lipitor), was the number one money-making drug for nearly a decade, at least up until 2011.241 The branded asthma medication Seretide, a top-ten revenue drug as of the mid-2000s, contains two active ingredients, one of which—fluticasone−is fluorinated.242
Even a single atom of fluorine added to a drug molecule can greatly change its chemical properties and thus how it interacts with the body.243 Replacing hydrogen with fluorine can protect drugs.244 Because of the considerable stability of the carbon–fluorine bond, many drugs are fluorinated in order to delay their metabolism and elimination. This allows longer times between doses.243 The introduction of fluorine can alter a molecule's shape so that it binds better to its target protein.244 Also, adding fluorine to organics increases their lipophilicity (ability to dissolve in fats) because the carbon–fluorine bond is even more hydrophobic than the carbon–hydrogen bond. This effect often increases a drug's bioavailability because of increased cell membrane penetration.242
Many modern antidepressants are fluorinated molecules that selectively limit the body's binding of serotonin (with low serotonin availability in brain cells being a cause of depression). Prior to the 1980s, traditional antidepressants, such as the tricyclics, altered not only serotonin uptake but also affected several other neurotransmitters. This non-selective interaction caused many side effects. One of the first medications to alter only serotonin uptake—and be free of most side effects of previous pharmaceuticals—was the fluorine-containing drug fluoxetine (Prozac). It became the best-selling antidepressant. Some other selective serotonin reuptake inhibitor (SSRI) antidepressants that are fluorinated are citalopram (Celexa) and its isomer escitalopram (Lexapro), fluvoxamine (Luvox), and paroxetine (Paxil).246247
Quinolones are artificial compounds that are broad-spectrum antibiotics. Most of the currently used quinolones are fluorinated to make the drugs more powerful. Prominent examples include ciprofloxacin (Cipro) and levofloxacin (Levaquin). The latter was the highest selling U.S. antibiotic in 2010.248249250251
Fluorine also finds use in many steroidal drugs.252 Fludrocortisone (Florinef) is a mineralocorticoid (a compound used to retain sodium and water and thus raise blood pressure).253 Triamcinolone and dexamethasone are potent glucocorticoids (anti-inflammatories).253
Several inhaled anesthetics, including the most common ones, are heavily fluorinated. The first fluorinated anesthetic, halothane, proved to be much safer (neither explosive nor flammable) and longer-lasting than those previously used. Modern fluorinated anesthetics are effective for even longer periods, and are almost insoluble in blood, allowing the patient to awaken more quickly. Examples include sevoflurane, desflurane, enflurane, and isoflurane, all of which are fluorinated ethers.254255
Fluorine-18 is routinely employed by the radiopharmaceutical industry, in particle accelerators, to produce radioactive tracers for positron emission tomography (PET) scanning. Its half-life of almost two hours is long enough to allow its transportation from the production facility to the imaging center for radiation exposure to patients. The most widely used radiopharmaceutical is fluorodeoxyglucose (FDG).256 After injection into the blood, FDG is taken up by tissues with a high need for glucose, such as the brain and most types of malignant tumors.257 Computer assisted tomography (CAT) can then be used for detailed imaging.258
Liquid fluorocarbons have a very high capacity for holding gas in solution. They can hold more oxygen or carbon dioxide than blood does and for that reason, have attracted ongoing interest as to their possible application in artificial blood, or liquid breathing.259
Blood substitutes are the subject of research because the demand for blood transfusions grows faster than donations. In some scenarios, artificial blood may be more convenient or safe. Because fluorocarbons do not normally mix with water, they must be mixed into emulsions (small droplets of perfluorocarbon suspended in water) to be used as blood.260261 One such product, Oxycyte, has been through initial clinical trials.262263 PFC doping has the potential to aid endurance athletes and is therefore banned from sports. One cyclist's mysterious near death in 1998 prompted an investigation for PFC abuse.264265
Possible medical uses of liquid breathing (which uses pure perfluorocarbon liquid, not a water emulsion) involve assistance for premature babies or for burn victims (because the normal lung function is compromised). Both partial filling of the lungs and complete filling of the lungs have been considered, although only the former has any significant tests in humans. Several animal tests, and some human partial liquid ventilation trials, have been conducted.266 One effort, by Alliance Pharmaceuticals reached clinical trials but was abandoned because the results were not better than normal therapies.267
An estimated 30% of agrichemical compounds contain fluorine.268 Most of them are herbicides and fungicides, but a few regulate crop growth. Fluorine substitution (usually of just a single atom or at most a trifluoromethyl group) is a powerful tool for new molecule design. The molecular effects—increasing biological stay time; membrane crossing; altering molecular recognition—are similar to those seen in fluorinated pharmaceuticals.269 Trifluralin is a prominent example, used widely in the U.S. as a weedkiller.269270 Its suspected carcinogenic properties have caused it to be banned in many European countries.271
Sodium monofluoroacetate (brand name 1080) is a commercial mammalian poison. The molecule is similar to the acetic acid molecule in vinegar but with a hydrogen atom changed out for fluorine atom (and another hydrogen atom changed out for a sodium atom). Fluoroacetate deprives cells of energy by replacing acetate in the Krebs cycle, halting a key part of cell metabolism. It was first synthesized in the late 19th century and then recognized as an insecticide in the early 20th century. Later, 1080 was widely used to control rats and other mammals. New Zealand is the largest consumer, using it to suppress the invasive Australian common brushtail possum, which threatens the indigenous kiwi.272 This particular poison is now banned in Europe and the U.S.note 20229273
Hydrofluoric acid, the water solution of hydrogen fluoride, is a contact poison. Even though it is chemically only a weak acid, it is far more dangerous than the conventional strong mineral acids, such as nitric acid, sulfuric acid, or hydrochloric acid. Owing to its lesser chemical dissociation in water (thereby remaining a neutral molecule), hydrogen fluoride penetrates tissue more quickly than typical acids. Poisoning can occur readily through the skin or eyes or when inhaled or swallowed. From 1984 to 1994, at least nine U.S. workers died from accidents with HF.274
Once in the blood, hydrogen fluoride reacts with calcium and magnesium, resulting in electrolyte imbalance (and potentially hypocalcemia). The consequent effect on the heart (cardiac arrhythmia) may be fatal.274 Formation of insoluble calcium fluoride also causes strong pain.276 Burns with areas larger than 160 cm2 (about the size of a person's hand) can cause serious systemic toxicity.277
Symptoms of exposure to hydrofluoric acid may not be immediately evident, with an 8-hour delay for 50% HF and up to 24 hours for lower concentrations. Hydrogen fluoride interferes with nerve function, meaning that burns may not initially be painful.
If the burn has been initially noticed, the HF should be washed off with a forceful stream of water for ten to fifteen minutes to prevent its further penetration into the body. Clothing used by the person burned may also present a danger.278 Hydrofluoric acid exposure is often treated with calcium gluconate, a source of calcium ions (Ca2+) that bind with the fluoride ions. Skin burns can be treated with a water wash and 2.5% calcium gluconate gel or special rinsing solutions.279280281 Because HF is absorbed, further medical treatment is necessary. Calcium gluconate may be injected or administered intravenously. Use of calcium chloride—a common laboratory reagent—in lieu of calcium gluconate is contraindicated, and may lead to severe complications. Sometimes surgical excision of tissue, or amputation, is required.277282
Soluble fluorides are moderately toxic. For sodium fluoride, the lethal dose for adults is 5–10 g, which is equivalent to 32–64 mg of elemental fluoride per kilogram of body weight.283 One fifth of the lethal dose may result in adverse health effects.284 Chronic excess fluoride consumption can lead to skeletal fluorosis, a disease of the bones that affects millions in Asia and Africa.284285
The fluoride ion is readily absorbed by the stomach and intestines. Ingested fluoride forms hydrofluoric acid in the stomach. In this form, it crosses cell membranes and then binds with calcium and interferes with various enzymes. The fluoride ion is excreted through urine. Exposure limits are based on urine testing, which determine the human body's capacity for ridding itself of fluoride ions.284286
Historically, most cases of fluoride poisoning have been caused by accidental ingestion of insecticides containing inorganic fluorides.287 Most current calls to poison control centers for possible fluoride poisoning come from the ingestion of fluoride-containing toothpaste.284 Malfunction of water fluoridation equipment has occurred several times, including an Alaskan incident that sickened nearly 300 people and killed one.288
Dangers from toothpaste are more serious for small children—the U.S. Centers for Disease Control and Prevention recommend children under six years of age be supervised when brushing their teeth so that they do not swallow toothpaste.289 One regional study examined a year of fluoride poisoning reports for pre-teens. Of 87 cases, there was one fatality (from insecticide). The other 86 were all from dental fluoride. Most had no symptoms, but about 30% had stomach pains, with symptoms more likely when more fluoride was consumed.287 A larger study of American fluoride poisoning reports showed similar findings; 80% of the reports were related to children under six. Few were serious, although several hundred cases were treated at health facilities each year.290
- Fluoride selective electrode, a device for measuring fluoride ion concentration
- Fluorine absorption dating, a relative dating technique for buried organic matter
- Fluorine NMR, an analytical technique for fluorine-containing molecules
- Fluorous chemistry, a process of separating reagents from organic solvents
- Krypton fluoride laser and argon fluoride laser, two ultraviolet lasers
- Alpha fluorine is solid and crystalline in that there is a regular pattern of repeated molecules. However, the diatomic molecules themselves are disordered within the crystal structure by random rotation. In contrast, in beta fluorine, the diatomic molecules are both fixed in location and have minimal rotational disorder. For further detail on alpha fluorine, see the 1970 structure by Pauling.42 For further detail on the concept of disorder in crystals, see the referenced general reviews.4344
- A loud click is heard. Samples may shatter and sample windows blow out.
- Exact comparison of the sizes of fluorine, oxygen and neon atoms is not possible because of conflicting estimates from different sources.
- The ratio of the angular momentum to magnetic moment is called the gyromagnetic ratio: 'Certain nuclei can for many purposes be thought of as spinning round an axis like the Earth or like a top. In general the spin endows them with angular momentum and with a magnetic moment; the first because of their mass, the second because all or part of their electric charge may be rotating with the mass.'53
- In this article, metalloids are lumped with the definite main group nonmetals because the fluoride chemistry is similar. The noble gases are treated separately. Hydrogen is discussed in the Hydrogen fluoride section; carbon in the Organic compounds section. The most recently created heavy elements have not been studied and thus are not included.
- It differs from this value in elemental fluorine, where the atoms are bonded to each other and thus at oxidation state 0. The very unstable anions F2- and F3- with intermediate oxidation states exist at very low temperatures, decomposing at around 40 K.73 The F4+ cation and a few related species have been predicted to be stable.74 Theoretical and experimental evidence for the short-lived existence of a fluoronium ion, in which a fluorine atom bridges two carbon atoms, and is positively charged, was reported in 2013.75
- Two cases of greater than single bonds are known: the metastable compounds boron monofluoride and nitrogen monofluoride. Fluorine may also act as a bridging ligand (less than single bond) between metals in some metal complexes. Molecules containing fluorine may also exhibit hydrogen bonding.
- ZrF4 melts at 932 °C.89 HfF4 sublimes at 968 °C.86 UF4 melts at 1036 °C.90
- IrF6, MoF6, OsF6, NpF6, PoF6, PuF6, PtF6, ReF6, RhF6, RuF6, TcF6, UF6, and WF6
- For more detail, see the explanation by Clark.108
- CF4 is formally an organic compound, but is noted here for structural comparison to SiF4 and GeF4. See the Organic compounds section for an overview of the vast number of fluorinated carbon-containing molecules.
- The term "fluorocarbon" is defined by IUPAC as being the same as a perfluorocarbon (a molecule with only carbon and fluorine), but in regular practice the usage is blurred, so that fluorocarbon often used for fluorinated organic molecules including those not fully fluorinated, especially in a commercial context.
- The term perfluorinated substance is also used for these molecules. In practice, terminology for classes of highly fluorinated molecules is imprecise. See the referenced summary of the terms used in the literature.137
- Fluorite was also described by alchemist "Basilius Valentinus", supposedly in the late 1400s. However, it is alleged that "Valentinus" was a hoax as his writings were not known until about 1600.149150151
- See the differing accounts of Partington154 and Weeks.155
- Since 2012, the symbol Fl has been used for flerovium (element 114), an artificially synthesized transuranic element.
- The injured included the English chemist Davy, the French chemists Joseph Louis Gay-Lussac and Louis Jacques Thénard, and the Irish chemists Thomas and George Knox. Belgian chemist Paulin Louyet and French chemist Jerome Nickles died. Moissan also experienced serious HF poisoning.155161
- Moissan's Nobel also honored his invention of the electric arc furnace
- The terminology is further muddled by the colloquial misuse of "Freon" to refer to now-banned CFCs, or to HFCs and HCFCs.
- A minor allowed use in the U.S. is in the collars of sheep and cattle to kill predators such as coyotes.
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