Functio laesa

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Functio laesa is a term used in medicine to refer to a loss of function12 or a disturbance of function.3

It was identified as the fifth sign of acute inflammation by Galen,4 who added it to the four signs identified by Celsus (tumor, rubor, calor, and dolor).

The attribution to Galen is disputed,3 and has variously been attributed to Thomas Sydenham5 and Rudolf Virchow.6


  1. ^ "Dorlands Medical Dictionary:cardinal signs". 
  2. ^ "Definition: functio laesa from Online Medical Dictionary". 
  3. ^ a b Rather LJ (March 1971). "Disturbance of function (functio laesa): The legendary fifth cardinal sign of inflammation, added by Galen to the four cardinal signs of Celsus". Bull N Y Acad Med 47 (3): 303–22. PMC 1749862. PMID 5276838. 
  4. ^ Porth, Carol (2007). Essentials of pahtophysiology: concepts of altered health states. Hagerstown, MD: Lippincott Williams & Wilkins. p. 270. ISBN 0-7817-7087-4. 
  5. ^ Dormandy, Thomas (2006). The worst of evils: man's fight against pain. New Haven, Conn: Yale University Press. p. 22. ISBN 0-300-11322-6. 
  6. ^ David Lowell Strayer; Raphael Rubin (2007). Rubin's Pathology: Clinicopathologic Foundations of Medicine 5th Edition. Hagerstown, MD: Lippincott Williams & Wilkins. p. 37. ISBN 0-7817-9516-8. 

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