Control of stomach acid
anatomy, the G cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells.
G cells are found deep within the
pyloric glands of the stomach antrum, and occasionally in the pancreas and 1 duodenum.
vagus nerve innervates the G cells.
Gastrin-releasing peptide is released by the post-ganglionic fibers of the vagus nerve onto G cells during parasympathetic stimulation. The peptide hormone bombesin also stimulates gastrin from G cells.
Gastrin-releasing peptide, as well as the presence of
amino acids in the stomach, stimulates the of gastrin from the G cells. Gastrin stimulates enterochromaffin-like cells to secrete histamine. 2
Gastrin also targets
parietal cells by increasing the amount of histamine and the direct stimulation by gastrin, causing the parietal cells to increase HCl secretion in the stomach.
G cells have a distinctive microscopic appearance that allows one to separate them from other cells in the gastric antrum; their nuclei are centrally located in the cell. They are found in the middle portion of the
^ "G cell", Medcyclopaedia ( GE), archived from the original on 2012-02-05
^ Guyton, Arthur C.; John E. Hall (2006). Textbook of Medical Physiology (11 ed.). Philadelphia: Elsevier Saunders. p. 797. ISBN 0-7216-0240-1.