H2BFWT

H2B histone family, member W, testis-specific
Identifiers
Symbol	H2BFWT
External IDs	OMIM: 300507 HomoloGene: 128214 GeneCards: H2BFWT Gene
Gene Ontology Molecular function • DNA binding • protein heterodimerization activity Cellular component • nucleosome • nuclear membrane Biological process • nucleosome assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	158983	n/a
Ensembl	ENSG00000123569	n/a
UniProt	Q7Z2G1	n/a
RefSeq (mRNA)	NM_001002916	n/a
RefSeq (protein)	NP_001002916	n/a
Location (UCSC)	Chr HG1441_PATCH: 103.27 – 103.27 Mb	n/a
PubMed search	[1]	n/a

H2B histone family, member W, testis-specific is a protein that in humans is encoded by the H2BFWT gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Jan 2010].

Further reading

• Churikov, D.; Zalenskaya, I. A.; Zalensky, A. O. (2004). "Male germline-specific histones in mouse and man". Cytogenetic and Genome Research 105 (2–4): 203–214. doi:10.1159/000078190. PMID 15237208. 
• Churikov, D.; Siino, J.; Svetlova, M.; Zhang, K.; Gineitis, A.; Morton Bradbury, E.; Zalensky, A. (2004). "Novel human testis-specific histone H2B encoded by the interrupted gene on the X chromosome". Genomics 84 (4): 745–756. doi:10.1016/j.ygeno.2004.06.001. PMID 15475252. 
• Boulard, M.; Gautier, T.; Mbele, G. O.; Gerson, V.; Hamiche, A.; Angelov, D.; Bouvet, P.; Dimitrov, S. (2006). "The NH2 Tail of the Novel Histone Variant H2BFWT Exhibits Properties Distinct from Conventional H2B with Respect to the Assembly of Mitotic Chromosomes". Molecular and Cellular Biology 26 (4): 1518–1526. doi:10.1128/MCB.26.4.1518-1526.2006. PMC 1367197. PMID 16449661. 
• Lee, J.; Park, H. S.; Kim, H. H.; Yun, Y. J.; Lee, D. R.; Lee, S. (2009). "Functional polymorphism in H2BFWT-5′UTR is associated with susceptibility to male infertility". Journal of Cellular and Molecular Medicine 13 (8b): 1942–1951. doi:10.1111/j.1582-4934.2009.00830.x. PMID 19583817.