In medicine, Hoffmann's sign, named after the German physiologist, Paul Hoffmann1234 (1884–1962, physiologist in Freiburg) is a distal sign of nerve regeneration.
A Hoffmann (or Tinel's sign) is a tingling sensation triggered by a mechanical stimulus in the distal part of an injured nerve. This sensation radiates peripherally, from the point where it is triggered to the cutaneous distribution of the nerve. The tingling response can be compared with that produced by a weak electric current, as in transcutaneous electrical nerve stimulation (TENS). This unpleasant sensation is not a severe pain and does not persist.5
In March 1915, Paul Hoffmann described the distal regeneration sign then baptised: Hoffmann's sign. In October 1915, Jules Tinel described the same phenomenon in French "le signe de fourmillement": Tinel's sign. In fact, the first to have described, in 1907, this phenomenon of sensory recovery were the British surgeons: Wilfred Trotter & H. Morriston Davies.67
- ^ synd/3740 at Who Named It?
- ^ Hoffmann. P. Über eine Methode, den Erfolg einer Nervennaht zu beurteilen. Medizinische Klinik, März 1915a, 13: 359-360
- ^ Hoffmann. P. Weiteres über das Verhalten frisch regenerierter Nerven und über eine Methode, den Erfolg einer Nervennaht zu beurteilen. Medizinische Klinik, October 1915b, 31: 856-858
- ^ Hoffmann, P. The Hoffmann-Tinel sign (Translated by Buck-Gramko D, Lubahn JD). J Hand Surg 1983, 18B, 800-805
- ^ Spicher C, Kohut G & Miauton J. At which stage of sensory recovery can a tingling sign be expected? A review and proposal for standardization and grading. J Hand Ther, 1999, 12:298-308
- ^ Trotter, W. & Davies, H.M. The exact determination of areas of altered sensibility. Review of Neurology & Psychiatry 1907, 5:761-772
- ^ Trotter, W. & Davies, H.M. Experimental studies in the innervation of the skin. J Physiol, 1909, 38:134-246