Immunostimulants, also known as immunostimulators, are substances (drugs and nutrients) that stimulate the immune system by inducing activation or increasing activity of any of its components. One notable example is the granulocyte macrophage colony-stimulating factor.
There are two main categories of immunostimulants:1
- Specific immunostimulants provide antigenic specificity in immune response, such as vaccines or any antigen.
- Non-specific immunostimulants act irrespective of antigenic specificity to augment immune response of other antigen or stimulate components of the immune system without antigenic specificity, such as adjuvants and non-specific immunostimulators.
Many endogenous substances are non-specific immunostimulators. For example, female sex hormones are known to stimulate both adaptive2 and innate immune responses.3 Some autoimmune diseases such as lupus erythematosus strike women preferentially, and their onset often coincides with puberty. Other hormones appear to regulate the immune system as well, most notably prolactin, growth hormone and vitamin D.45
Some publications point towards the effect of deoxycholic acid (DCA) as an immunostimulant678 of the unspecific immune system, activating its main actors, the macrophages. According to these publications, a sufficient amount of DCA in the human body corresponds to a good immune reaction of the unspecific immune system.
- Deoxycholic acid, a stimulator of macrophages
- Macrokine, a stimulator of macrophages
- Imiquimod and resiquimod, activate immune cells through the toll-like receptor 7
- Kumar, S; Gupta P, Sharma S, Kumar D (2011). "A review on immunostimulatory plants". Journal of Chinese Integrative Medicine 9 (2): 117–128. doi:10.3736/jcim20110201. PMID 21288444.
- Wira, CR; Crane-Godreau M, Grant K (2004). "Endocrine regulation of the mucosal immune system in the female reproductive tract". In In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J (eds.). Mucosal Immunology. San Francisco: Elsevier. ISBN 0-12-491543-4.
- Lang, TJ (2004). "Estrogen as an immunomodulator". Clin Immunol 113 (3): 224–230. doi:10.1016/j.clim.2004.05.011. PMID 15507385.
Moriyama, A; Shimoya K, Ogata I et al. (1999). "Secretory leukocyte protease inhibitor (SLPI) concentrations in cervical mucus of women with normal menstrual cycle". Molecular Human Reproduction 5 (7): 656–661. doi:10.1093/molehr/5.7.656. PMID 10381821.
Cutolo, M; Sulli A, Capellino S, Villaggio B, Montagna P, Seriolo B, Straub RH (2004). "Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity". Lupus 13 (9): 635–638. doi:10.1191/0961203304lu1094oa. PMID 15485092.
King, AE; Critchley HOD, Kelly RW (2000). "Presence of secretory leukocyte protease inhibitor in human endometrium and first trimester decidua suggests an antibacterial role". Molecular Human Reproduction 6 (2): 191–196. doi:10.1093/molehr/6.2.191. PMID 10655462.
- Dorshkind, K; Horseman ND (2000). "The Roles of Prolactin, Growth Hormone, Insulin-Like Growth Factor-I, and Thyroid Hormones in Lymphocyte Development and Function: Insights from Genetic Models of Hormones and Hormone Receptor Deficiency". Endocrine Reviews 21 (3): 292–312. doi:10.1210/er.21.3.292. PMID 10857555.
- Nagpal, Sunil; Songqing Naand and Radhakrishnan Rathnachalam (2005). "Noncalcemic Actions of Vitamin D Receptor Ligands". Endocrine Reviews 26 (5): 662–687. doi:10.1210/er.2004-0002. PMID 15798098.
- Vlcek, B; Reif, A; Seidlová, B (1971). "Evidence of the participation of deoxycholate in cancer immunity". Zeitschrift fur Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie 26 (5): 419–24. PMID 4398280.
- Vlček, B (1972). "Potentiation of the immune response with DCA". Prakt. Lekar 52: 326–330. (Czech)
- Chyle, M; Chyle, P (1982). "Regulation of the immune response with DCA". Sbornik lek. 84: 212–218. (Czech) (English summary)
- Veterinary Immunology and Immunopathology journal
- Immunostimulants at the US National Library of Medicine Medical Subject Headings (MeSH)
- Deoxycholic acid as immunostimulant
|This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.|