Rebek was born in Beregszasz (Berehove),in Hungary, now Ukraine in 1944 and lived in Austria from 1945 to 1949. In 1949 he and his family immigrated to the United States and settled in Kansas. Rebek graduated from the University of Kansas with a Bachelor of Arts degree in chemistry. Rebek received his Master of Arts degree and his Ph.D. in organic chemistry from the Massachusetts Institute of Technology in 1970. There he studied peptides under D.S. Kemp.
Rebek was an assistant professor at the University of California at Los Angeles from 1970 to 1976. There he developed the three-phase test for reactive intermediates. In 1976, he moved to the University of Pittsburgh, where he developed cleft-like structures for studies in molecular recognition. In 1989 he returned to MIT, where he became the Camille Dreyfus Professor of Chemistry and devised synthetic, self-replicating molecules. In July 1996, he moved his research group to the Scripps Research Institute to become the director of the Skaggs Institute for Chemical Biology, where he continues to work in molecular recognition and self-assembling systems.
Rebek is a member of the National Academy of Sciences.
Rebek’s independent research began in 1970s, with a method to detect reactive intermediates. This was invented through application of polymer-bound reagents. A precursor for the reactive intermediate was covalently attached to one solid phase while a trap was attached to a second such support. When transfer takes place between the solid phases, it requires the existence of a reactive intermediate, free in solution as shown below. Among the reactive species detected by this “Three Phase Test” were cyclobutadiene, singlet oxygen, monomeric metaphosphate, and acyl imidazoles.
A model of the Pauling principle - catalysis by maximum binding to the transition state – was devised in 1978. A physical processes, the racemization of the bipyridyl shown below was chosen. The transition structure features coplanar aryl rings and a binding force — the chelation of a metal by bipyridyl —shows maximum metal/ligand attraction at the coplanar geometry. 1 The biaryl bond acts like a fulcrum and binding induces a mechanical stress elsewhere in a molecule. This was one of the first molecular machines, a rotor.
Other bipyridyls and biphenyls were designed in the 1980s as synthetic models of allosteric effects shown below. One involved two identical and mechanically coupled binding sites and it showed positive cooperativity in binding of covalent mercury compounds. 2 3 Rotors are still the most frequent chemical models for allosteric effects, and are present in many of the molecular machines pursued in other laboratories today.
Efforts in molecular recognition in the 1980s, led to cleft-like shapes 4 for recognition of ions and especially nonionic targets. Using derivatives of Kemp’s triacid, Rebek arranged functional groups that “converged” to create a recognition site. Shown above is a bisimide that chelates adenine in water. 5 Versions with carboxyl groups6 became widely used elsewhere as models for metalloenzymes (the XDK structures) 7 and in Rebek’s laboratory to probe stereoelectronic effects.
In 1990, these studies culminated in a synthetic, self-complementary that acted as a template for its own formation. It showed autocatalysis based on molecular recognition and was the first synthetic system to show a primitive sign of life: self-replication. "Self-replicating system. Tjivikua, T., Ballester, P., Rebek, J., Jr. J. Am. Chem. Soc. 1990, 112:1249.". Retrieved 2011-08-05. The template grasps the reactants by hydrogen bonding at both ends as indicated below. The self-complementary “recipe” has been incorporated universally in self-replicating systems synthesized in other research groups.
Philip Ball in his book, Designing the Molecular World, argues that Rebek's self replicating molecules share some criteria with both nucleic acids and proteins and, moreover, “their replications operates according to novel kind of molecular interaction rather than mimicking the complementarity base pairing of nucleic acids. One could view this as an indication that perhaps DNA is not the sine qua none of life, so that one might conceive of organisms that "live" according to completely different molecular principles.” He suggests that Rebek has been able to pursue the idea of “molecular “evolution” by making artificial replicators that can be mutated. … The considerable excitement that has greeted Julius Rebek’s work is inspired in part by the possibilities that it raises for exploring the kind of chemical processes that led to the appearance of life on our planet.”
British ethologist Richard Dawkins in his book, River out of Eden, suggests that Rebek's replicating molecules “raise the possibility of other worlds having a parallel evolution [to Earth's] but with a fundamentally different chemical basis."
Through collaboration with Javier de Mendoza in 1993, Rebek managed to create a self-assembling capsule. These form reversibly by completely surrounding small molecule targets 8 and have become a versatile tool of modern physical organic chemistry. They exist in solution at equilibrium and under ambient conditions. They act as nanometric reaction chambers, as means to stabilize reagents, as sources of “complexes within complexes” and as spaces where new forms of stereochemistry have been created. They also inspired encapsulation in other research groups that use metal-ligand interactions for self-assembly. A cylindrical capsule of nanometric dimensions 9 is shown above; it selects congruent guests singly or pairwise when the space inside is appropriately filled.
Richard Dawkins writes about autocatalysis as a potential explanation for abiogenesis in his 2004 book The Ancestor's Tale. He cites experiments performed by Julius Rebek and his colleagues at the Scripps Research Institute in California in which they combined amino adenosine and pentafluorophenyl ester with the autocatalyst amino adenosine triacid ester (AATE). One system from the experiment contained variants of AATE which catalysed the synthesis of themselves. This experiment demonstrated the possibility that autocatalysts could exhibit competition within a population of entities with heredity, which could be interpreted as a rudimentary form of natural selection.
- 1970-1976: Assistant Professor, University of California Los Angeles, Los Angeles, CA
- 1976-1979: Associate Professor, University of Pittsburgh, Pittsburgh, PA
- 1980-1989: Professor, University of Pittsburgh, Pittsburgh, PA
- 1989-1991: Professor, Massachusetts Institute of Technology, Cambridge, MA
- 1991-1996: Camille Dreyfus Prof. of Chemistry Massachusetts Institute of Technology, Cambridge, MA
- 1996–present: Director, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA
- 1967-1970: National Science Foundation pre-doctoral fellow
- 1976-1974: Eli Lilly Award
- 1976-1978: A.P. Sloan Fellow
- 1981: Alexander von Humboldt Fellow
- 1986: Guggenheim Fellow
- 1990: Myron L. Bender and Muriel S. Bender Distinguished Summer Lecturer in Organic Chemistry, Northwestern University
- 1991: A.C. Cope Scholar Award
- 1993: American Academy of Arts and Sciences
- 1994: National Academy of Science
- 1996: MERIT Award (National Institutes of Health)
- 1997: James Flack Norris Award in Physical Organic Chemistry (American Chemical Society)
- 2001: Hungarian Academy of Sciences
- 2002: Chemical Pioneer Award (American Institute of Chemists)
- 2004: Ronald Breslow Award for Achievement in Biomimetic Chemistry (American Chemical Society)
- 2005: Medal of the Academy of Sciences; Prague, Czech Republic
- 2005: Medal of the National Academy of Sciences, Letters and Arts; Modena, Italy
- 2005: European Academy of Science (Academia Europaea) Member
- Rebek, J. (1979), "Mechanistic studies using solid supports: the three-phase test", Tetrahedron 36 (6): 723–731, doi:10.1016/0040-4020(79)80087-3, retrieved 2011-08-05
- Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J (July 2004). "Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests". Proc. Natl. Acad. Sci. U.S.A. 101 (28): 10470–5. Bibcode:2004PNAS..10110470B. doi:10.1073/pnas.0403802101. PMC 478593. PMID 15240875.
- Davis CN, Mann E, Behrens MM, Gaidarova S, Rebek M, Rebek J, Bartfai T (February 2006). "MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics". Proc. Natl. Acad. Sci. U.S.A. 103 (8): 2953–8. Bibcode:2006PNAS..103.2953D. doi:10.1073/pnas.0510802103. PMC 1413805. PMID 16477040.
- "On binding to transition states and ground states: remote catalysis. Rebek, J., Jr. Trend, J.E. J. Am. Chem. Soc. 1978, 100:4315.". Retrieved 2011-08-05.
- Allosterische Effekte: Bindungskooperativität in einer Modellverbindung mit Untereinheiten. Rebek, J., Jr. Wattley, R.V., Costello, T., Gadwood, R., Marshall, L. Angew. Chem. Int. Ed. 1981, 93:584. doi:10.1002/ange.19810930617.
- Binding forces, equilibria and rates: new models for enzymic catalysis. Rebek, J., Jr. Acc. Chem. Res. 1984, 17:258.. doi:10.1021/ar00103a006. Retrieved 2011-08-05.
- Rebek J (March 1987). "Model studies in molecular recognition". Science 235 (4795): 1478–84. Bibcode:1987Sci...235.1478R. doi:10.1126/science.3823899. PMID 3823899.
- Kato Y, Conn MM, Rebek J (February 1995). "Hydrogen bonding in water using synthetic receptors". Proc. Natl. Acad. Sci. U.S.A. 92 (4): 1208–12. Bibcode:1995PNAS...92.1208K. doi:10.1073/pnas.92.4.1208. PMC 42668. PMID 7862662.
- Marshall, L.R., Parris, K., Rebek, J., Jr., Luis, S.V., Burguete, M.I. J. Am. Chem. Soc. 1988, 110:5192.
- "Synthesis, Structure, and Reactivity of (.mu.-Oxo)bis(.mu.-carboxylato)diiron(III) Complexes of a Dinucleating Dicarboxylate Ligand, a Kinetically Stable Model for Non-Heme Diiron Protein Cores. Watton, S., Masschelein, A., Rebek, J., Jr., Lippard, S.J. J. Am. Chem. Soc. 1994, 116:5196.". Retrieved 2011-08-05.
- Conn, M.M.; Rebek, J. (1997), "Self-assembly capsules", Chem. Rev. 97: 1647
- "Access : Pairwise selection of guests in a cylindrical molecular capsule of nanometre dimensions. Heinz, T., Rudkevich, D.M., Rebek, J., Jr. Nature 1998, 394:764". Retrieved 2011-08-05.
- Haberhauer, Gebhard; Somogyi, László; Rebek, Julius (2000), "Synthesis of a second-generation pseudopeptide platform", Tetrahedron Letters 41 (26): 5013–5016, doi:10.1016/S0040-4039(00)00796-6, retrieved 2011-08-05