KCNU1

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Potassium channel, subfamily U, member 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KCNU1 ; KCNMC1; KCa5; KCa5.1; Kcnma3; Slo3
External IDs MGI1202300 HomoloGene7392 IUPHAR: KCa5.1 GeneCards: KCNU1 Gene
Orthologs
Species Human Mouse
Entrez 157855 16532
Ensembl ENSG00000215262 ENSMUSG00000031576
UniProt A8MYU2 O54982
RefSeq (mRNA) NM_001031836 NM_008432
RefSeq (protein) NP_001027006 NP_032458
Location (UCSC) Chr 8:
36.64 – 36.79 Mb
Chr 8:
25.85 – 25.94 Mb
PubMed search [1] [2]

Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the KCa5.1 protein.1

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.234

References

  1. ^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476. 
  2. ^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.". Pharmacol Rev 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. 
  3. ^ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K+ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554. 
  4. ^ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K+ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555. 

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

Further reading

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).









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