Uterine fibroids are leiomyomata of the uterine smooth muscle. As other leiomyomata, they are benign, but may lead to excessive menstrual bleeding (menorrhagia), often cause anemia and may lead to infertility.
A rare form of these tumors is uterine lipoleiomyoma - benign tumors consisting of a mixture of adipocytes and smooth muscle cells. Uterine lipoleiomyomata have been observed together with ovarian and other pathologies and some of them may develop into liposarcoma.123 These tumors are monoclonal, and non-random chromosomal abnormalities have seen in 40% of the tumors.
Mesenchymal neoplasms of the gallbladder are rare and in particular leiomyomas of the gallbladder have been rarely reported, all of them in patients with immune system disorders. Although, recently, a case was reported in absence of associated immunodeficiency. 4
Leiomyomas of the skin are generally (1) acquired, and (2) divided into several categories:56
Leiomyoma is the most common benign tumor of small bowel. Approximately 50% of cases are found in the jejunum, followed by the ileum in 31% of cases. Almost one half of all lesions are less than 5 centimeters.7
Other locations, metastatic leiomyoma
metastatic leiomyoma are an extremely rare complication after hysterectomy for uterine fibroids. Most frequent sites of occurrence are the lungs and pelvis, the lesions are hormonally responsive.8910
fibromyoma of the breast is an extremely rare benign breast neoplasm. Most reports in literature mention a history of hysterectomy for uterine fibroids, although the question whether these fibromyomas are possibly metastases of the uterine fibroids has not been investigated. An alternative hypothesis is an origin from the smooth muscle of the nipple.
^McDonald, A. G.; Cin, P. D.; Ganguly, A.; Campbell, S.; Imai, Y.; Rosenberg, A. E.; Oliva, E. (2011). "Liposarcoma Arising in Uterine Lipoleiomyoma". The American Journal of Surgical Pathology35 (2): 221–227. doi:10.1097/PAS.0b013e31820414f7. PMID21263242.
^Walid MS, Heaton RL. "Case report of a cervical lipoleiomyoma with an incidentally discovered ovarian granulosa cell tumor – imaging and minimal-invasive surgical procedure". GMS Ger Med Sci8 (26).
^Segura-Sampedro, J. J.; Alamo-Martínez, J. M.; Cañete-Gómez, J.; Suárez-Artacho, G.; González-Cantón, J. R.; Gómez-Bravo, M. Á.; Padillo-Ruiz, F. J. (2012). "Gallbladder leiomyoma in absence of immune system disorders: An unusual diagn". Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva104 (7): 382–384. doi:10.4321/S1130-01082012000700009. PMID22849501.
^Freedberg, Irwin M.; Fitzpatrick, Thomas B. (2003). Fitzpatrick's dermatology in general medicine (6th ed.). New York: McGraw-Hill, Medical Pub. Division. p. 1033. ISBN0-07-138076-0.
^Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology (10th ed.). Saunders Elsevier. p. 627. ISBN0-7216-2921-0.
^Patton, K.; Cheng, L.; Papavero, V.; Blum, M.; Yeldandi, A.; Adley, B.; Luan, C.; Diaz, L.; Hui, P.; Yang, X. J. (2006). "Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis". Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc19 (1): 130–140. doi:10.1038/modpathol.3800504. PMID16357844.
^Beck, M. M.; Biswas, B.; d'Souza, A.; Kumar, R. (2012). "Benign metastasising leiomyoma after hysterectomy and bilateral salpingo-oophorectomy". Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine18 (2): 153–155. PMID22477740.
^Rivera, J. A.; Christopoulos, S.; Small, D.; Trifiro, M. (2004). "Hormonal Manipulation of Benign Metastasizing Leiomyomas: Report of Two Cases and Review of the Literature". Journal of Clinical Endocrinology & Metabolism89 (7): 3183–3188. doi:10.1210/jc.2003-032021. PMID15240591.