As a coach, he earned the distinction of being the first and so far only coach to lead Torino to the Scudetto since the Superga tragedy in 1949, when they won the title in the 1975-1976 season.
Radice has also coached a number of other Serie A teams, including Inter, Roma and Fiorentina, as well as Cesena when the team was in the lower division.
In the 1992-1993 season Fiorentina was entrusted to Radice. The team started well, and at the turn of the year was sitting in second place, having scored 15 points in the first 13 matches. However, a mid-season feud with the club's chairman Vittorio Cecchi Gori led to the departure of Radice, and Fiorentina nose-dived in the standings. They scored only 15 more points in the remaining 21 matches, and finished only 16th. The result was relegation to Serie B.