Mannose 6-phosphate receptors (MPRs) deliver lysosomalhydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.2
The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,3 despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for lipid droplets.4
^Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR. (May 2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47.". Science292 (5520): 1373–6. doi:10.1126/science.1056791. PMID11359012.
^Brasaemle DL (December 2007). "Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis". J. Lipid Res.48 (12): 2547–59. doi:10.1194/jlr.R700014-JLR200. PMID17878492.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Than NG, Sumegi B, Than GN, et al. (1999). "Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein.". Tumour Biol.20 (4): 184–92. doi:10.1159/000030062. PMID10393528.
Krise JP, Sincock PM, Orsel JG, Pfeffer SR (2000). "Quantitative analysis of TIP47-receptor cytoplasmic domain interactions: implications for endosome-to-trans Golgi network trafficking.". J. Biol. Chem.275 (33): 25188–93. doi:10.1074/jbc.M001138200. PMID10829017.
Miura S, Gan JW, Brzostowski J, et al. (2002). "Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium.". J. Biol. Chem.277 (35): 32253–7. doi:10.1074/jbc.M204410200. PMID12077142.
Than NG, Sumegi B, Bellyei S, et al. (2003). "Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells.". Eur. J. Biochem.270 (6): 1176–88. doi:10.1046/j.1432-1033.2003.03475.x. PMID12631276.
Nair P, Schaub BE, Rohrer J (2003). "Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor.". J. Biol. Chem.278 (27): 24753–8. doi:10.1074/jbc.M300174200. PMID12697764.