Metrifonate

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Metrifonate
Trichlorfon.PNG
Systematic (IUPAC) name
(RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Pharmacokinetic data
Half-life 3 hours
Identifiers
CAS number 52-68-6 YesY
ATC code P02BB01 QP52AB01 QP53AF02
PubChem CID 5853
UNII DBF2DG4G2K YesY
KEGG C07971 YesY
Synonyms Trichlorphon
Chemical data
Formula C4H8Cl3O4P 
Mol. mass 257.436 g/mol
 YesY (what is this?)  (verify)

Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor.1 It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate (DDVP).

It is used as an insecticide.

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.2

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.3

References

  1. ^ "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease". 
  2. ^ Ross A.G.P., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., and McManus D.P. (2002). "Schistosomiasis". The New England Journal of Medicine 346 (16): 1212–1220. doi:10.1056/NEJMra012396. PMID 11961151. 
  3. ^ López-Arrieta J, Schneider L (2008). "Metrifonate for Alzheimer's disease". In López-Arrieta, Jess. Cochrane Database of Systematic Reviews (1): CD003155. doi:10.1002/14651858.CD003155.pub3. PMID 16625573. 







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