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Best Viewed With GFS!Niperotidine
From Wikipedia, the free encyclopedia
| Niperotidine | |
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(Z)-N-(1,3-benzodioxol-5-ylmethyl)-N'-{2[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}-2-nitroethylene-1,1-diamine |
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| Identifiers | |
| CAS number | 84845-75-0  |
| PubChem | 3033952 |
| KEGG | D07072 |
| MeSH | Niperotidine |
| ChEMBL | CHEMBL1909284 |
| ATC code | A02 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C20H26N4O5S |
| Molar mass | 434.50924 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Niperotidine is a histamine antagonist selective for the H2 subtype. It was trialled as a treatment for excessive gastric acidity,1 but withdrawn after human trials showed liver damage.2
Adverse effects
Antacid preparations such as niperotidine by suppressing acid mediated break down of proteins, leads to an elevated risk of developing food or drug allergies. This happens due to undigested proteins then passing into the gastrointestinal tract where sensitisation occurs. It is unclear whether this risk occurs with only long-term use or with short-term use as well.3
References
- ^ Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Italian Journal of Gastroenterology. 1990 Oct;22(5):291-4. PMID 1983712
- ^ Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. Journal of Hepatology. 1997 Sep;27(3):583-6. PMID 9314138
- ^ Pali-Schöll I, Jensen-Jarolim E (April 2011). "Anti-acid medication as a risk factor for food allergy". Allergy 66 (4): 469–77. doi:10.1111/j.1398-9995.2010.02511.x. PMID 21121928.
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