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Poison is a substance that causes injury, illness, or death.
Poison or The Poison may also refer to:
- Poison (comics), a Marvel Comics heroine with toxic, poisonous abilities.
- Poison (Final Fight), a character in the Final Fight and Street Fighter video-game series
- Poison (film), a 1991 film directed by Todd Haynes
- Poison (House), a 2005 episode of House
- "Poison" (Law & Order: Criminal Intent), an episode of Law & Order: Criminal Intent
- "Poison" (story), by Roald Dahl
- Poison (Kielland novel), by Alexander Kielland
- Poison (Wooding novel), by Chris Wooding
- Poison (American band), an American glam metal band
- Poison (German band), a German black metal band
- Poison (Secret EP), 2012
- "Poison" (Secret song), 2012
- Poison (album), a 1990 album by Bell Biv DeVoe
- "Poison" (Bell Biv DeVoe song), a 1990 song
- "Poison", a 1990 song by Kool G. Rap & DJ Polo from Wanted: Dead or Alive (this song is sampled in the chorus of "Poison" by Bell Biv Devoe)
- The Poison, an album by Bullet For My Valentine
- The Poison: Live at Brixton, a DVD by Bullet For My Valentine
- Poison (Groove Coverage EP), 2004
- "Poison" (Alice Cooper song), a 1989 song
- "Poison" (Bardot song), a 2000 song
- "Poison" (Nicole Scherzinger song), a 2011 song
- "Poison" (The Prodigy song), a 1995 song
- "Poison", a song by All Time Low from Nothing Personal
- "Poison", a song by Beyoncé Knowles from I Am... Sasha Fierce.
- "Poison", a song by Hot Water Music from The New What Next
- "Poison", a song by Lisa Stansfield from her debut album Affection
- "Poison", a song by Martina Topley-Bird from The Blue God
- "Poison", a song by Motörhead from Bomber
- "Poison", a song by Takashi Sorimachi from the live-action drama Great Teacher Onizuka
- "The Poison", a song by Pedro the Lion from Achilles Heel
- Nuclear poison, a neutron-absorbent material that impedes an intended nuclear reaction
- Poison, a fragrance by Dior
- Poison-type, a type of Pokémon in the video game series
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