R-type calcium channel

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Calcium channel, voltage-dependent, R type, alpha 1E subunit
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CACNA1E ; BII; CACH6; CACNL1A6; Cav2.3
External IDs OMIM601013 MGI106217 HomoloGene20185 IUPHAR: Cav2.3 ChEMBL: 1687682 GeneCards: CACNA1E Gene
Orthologs
Species Human Mouse
Entrez 777 12290
Ensembl ENSG00000198216 ENSMUSG00000004110
UniProt Q15878 Q61290
RefSeq (mRNA) NM_000721 NM_009782
RefSeq (protein) NP_000712 NP_033912
Location (UCSC) Chr 1:
181.38 – 181.78 Mb
Chr 1:
154.39 – 154.73 Mb
PubMed search [1] [2]

The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms the pore through which calcium enters the cell and determines most of the channel's properties. This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 which in humans is encoded by the CACNA1E gene.123 They are strongly expressed in cortex, hippocampus, striatum, amygdala and interpeduncular nucleus. 4

They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.

References

  1. ^ "Entrez Gene: CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit". 
  2. ^ Soong TW, Stea A, Hodson CD, Dubel SJ, Vincent SR, Snutch TP (May 1993). "Structure and functional expression of a member of the low voltage-activated calcium channel family". Science 260 (5111): 1133–6. doi:10.1126/science.8388125. PMID 8388125. 
  3. ^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. 
  4. ^ Parajuli, LK; Nakajima C, Kulik A, Matsui K, Schneider T, Shigemoto R, Fukazawa Y (September 2012). "Quantitative regional and ultrastructural localization of the Ca(v)2.3 subunit of R-type calcium channel in mouse brain". J Neurosci 32 (39): 13555–67. PMID 23015445. 

Further reading

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