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The River Looe (Cornish: Logh, meaning deep water inlet) is a river in south-east Cornwall, which flows into the English Channel at Looe. It has two main branches, the East Looe River and the West Looe River.
The eastern tributary has its source near St Cleer and flows south, passing close to the western outskirts of Liskeard. The western tributary has its source near Dobwalls.
South of Liskeard, the Looe Valley Line railway follows the course of the river to Looe.