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Syntaxin binding protein 1

PDB rendering based on 1dn1.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols STXBP1 ; MUNC18-1; NSEC1; P67; RBSEC1; UNC18
External IDs OMIM602926 MGI107363 HomoloGene2382 GeneCards: STXBP1 Gene
RNA expression pattern
PBB GE STXBP1 202260 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6812 20910
Ensembl ENSG00000136854 ENSMUSG00000026797
UniProt P61764 O08599
RefSeq (mRNA) NM_001032221 NM_001113569
RefSeq (protein) NP_001027392 NP_001107041
Location (UCSC) Chr 9:
130.37 – 130.46 Mb
Chr 2:
32.79 – 32.85 Mb
PubMed search [1] [2]

Syntaxin-binding protein 1 is a protein that in humans is encoded by the STXBP1 gene.12

In melanocytic cells STXBP1 gene expression may be regulated by MITF.3


STXBP1 has been shown to interact with STX2,45 STX445 and STX1A.56789


  1. ^ Swanson DA, Steel JM, Valle D (Jun 1998). "Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release". Genomics 48 (3): 373–6. doi:10.1006/geno.1997.5202. PMID 9545644. 
  2. ^ "Entrez Gene: STXBP1 syntaxin binding protein 1". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  4. ^ a b Schraw, Todd D; Lemons Paula P, Dean William L, Whiteheart Sidney W (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. (England) 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. ISSN 0264-6021. PMC 1223584. PMID 12773094. 
  5. ^ a b c Hata, Y; Südhof T C (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. (UNITED STATES) 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. ISSN 0021-9258. PMID 7768895. 
  6. ^ Bhaskar, Kiran; Shareef Mohammed Momin, Sharma Vandana M, Shetty A Pavan Kumar, Ramamohan Y, Pant Harish C, Raju T R, Shetty K Taranath (Jan 2004). "Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins". Neurochem. Int. (England) 44 (1): 35–44. doi:10.1016/S0197-0186(03)00099-8. ISSN 0197-0186. PMID 12963086. 
  7. ^ Dulubova, I; Sugita S, Hill S, Hosaka M, Fernandez I, Südhof T C, Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". EMBO J. (ENGLAND) 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. ISSN 0261-4189. PMC 1171512. PMID 10449403. 
  8. ^ McMahon, H T; Missler M, Li C, Südhof T C (Oct 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell (UNITED STATES) 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. ISSN 0092-8674. PMID 7553862. 
  9. ^ Pérez-Brangulí, Francesc; Muhaisen Ashraf, Blasi Juan (Jun 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Mol. Cell. Neurosci. (United States) 20 (2): 169–80. doi:10.1006/mcne.2002.1122. ISSN 1044-7431. PMID 12093152. 

Further reading

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