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A serenic, or antiaggressive agent, is a type of drug which inhibits social feelings of irritability, aggression, and anger. Many commonly induce the opposite of effects as well, including empathy, compassion, and affection.

A more powerful type of serenic which also produces prominent antidepressant, anxiolytic, and euphoriant effects is known as an entactogen, the classic example of which is the recreational drug MDMA ("Ecstasy"), along with the other MDxx derivatives. Such agents have been known to induce feelings even as strong as love.

Most serenics (as well as entactogens) are thought to work through the monoamine (especially serotonin) and oxytocin neurotransmitter systems. Examples of such agents include serotonergics like serotonin reuptake inhibitors (SRIs), serotonin releasing agents (SRAs), and 5-HT1A agonists, as well as oxytocin receptor agonists, among others. In the future, serenics may someday be developed and utilized in the clinical treatment of anger disorders.


Verhoeven, W.M.A., & Tuinier, S.. (2007). Serenics: Anti-aggression drugs throughout history. Clinical Neuropsychiatry: journal of treatments evaluation, 135–143. Retrieved from

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