Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.
Model organisms have been used in the study of TRPC4AP function. A conditional knockout mouse line, called Trpc4ap tm1a(KOMP)Wtsi 6 was generated as part of the 7 International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. 8 9 10
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion. 4 Twenty five tests were carried out on 11 mutant mice and three significant abnormalities were observed. Few 4 homozygous mutant embryos were identified during gestation, and thus fewer than expected survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; females had an abnormal anagen phase of the hair cycle. 4
TRPC4AP has been shown to
interact with TNFRSF1A. 12
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^ Soond, Surinder M; Terry Jennifer L, Colbert Jeff D, Riches David W H (Nov 2003). "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB". Mol. Cell. Biol. (United States) 23 (22): 8334–44. doi: 10.1128/MCB.23.22.8334-8344.2003. ISSN 0270-7306. PMC 262424. PMID 14585990.