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As of 2010, the city has an estimated population of 353,881 and a population density of 3,360 persons per km². The total area is 105.31 km².
The city was founded on January 1, 1943 and is located almost directly between Kyoto and Osaka. Due to the convenience of being 13–15 minutes away from Kyoto and Osaka by train respectively, the city has developed exponentially during the last 20 years. It is a commuter town, with people commuting to both Kyoto and Osaka.
Takatsuki-shi is serviced by two train lines: JR (Japan Railway Company) and Hankyu. Many people prefer to ride on the JR line, due to the JR's cheaper fares and slightly more frequent service. When the JR Fukuchiyama Line crashed and caused 108 casualties in 2005, the number of people using JR dropped compared to Hankyu, but has recovered since. Takatsuki is one of the larger suburban cities outlying central Osaka, so almost every train stops at this station. The Sakaisuji Line terminates at the Takatsuki-shi Station, while it sometimes comes from the Kawaramachi Stationdisambiguation needed.