VDAC2

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Voltage-dependent anion channel 2
Identifiers
Symbols VDAC2 ; POR
External IDs OMIM193245 MGI106915 HomoloGene37765 ChEMBL: 6190 GeneCards: VDAC2 Gene
Orthologs
Species Human Mouse
Entrez 7417 22334
Ensembl ENSG00000165637 ENSMUSG00000021771
UniProt P45880 Q60930
RefSeq (mRNA) NM_001184783 NM_011695
RefSeq (protein) NP_001171712 NP_035825
Location (UCSC) Chr 10:
76.97 – 76.99 Mb
Chr 14:
21.83 – 21.85 Mb
PubMed search [1] [2]

Voltage-dependent anion-selective channel protein 2 is a protein that in humans is encoded by the VDAC2 gene.12 The protein encoded by this gene is a voltage-dependent anion channel.12

VDAC2 is involved in the regulation of mitochondrial apoptosis.3

References

  1. ^ a b Blachly-Dyson E, Baldini A, Litt M, McCabe ER, Forte M (Jul 1994). "Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms". Genomics 20 (1): 62–7. doi:10.1006/geno.1994.1127. PMID 7517385. 
  2. ^ a b Messina A, Oliva M, Rosato C, Huizing M, Ruitenbeek W, van den Heuvel LP, Forte M, Rocchi M, De Pinto V (Apr 1999). "Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered". Biochem Biophys Res Commun 255 (3): 707–10. doi:10.1006/bbrc.1998.0136. PMID 10049775. 
  3. ^ Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ (July 2003). "VDAC2 inhibits BAK activation and mitochondrial apoptosis". Science 301 (5632): 513–7. doi:10.1126/science.1083995. PMID 12881569. 

Further reading

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