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WTIU also has two digital subchannels: TIU-2, which features educational programming and telecourses; plus TIU-HD, which features high-definition programming, on a schedule separate from WTIU's main channel.
WTIU's flagship original production is The Weekly Special, a public and cultural affairs program.
The Friday Zone, the only other regular weekly original production by WTIU, is also the only produced, edited and aired children's show in the state of Indiana.
WTIU regularly produces documentaries, typically on local or regional topics. Series documentaries include Our Town, focusing on a single community's culture and history, and The Spirit of Monroe County, which explores what makes Monroe County, Indiana the place it is.